Interleukin-10 promoter gene polymorphisms and susceptibility to asthma: a meta-analysis.
Interleukin-10 promoter gene polymorphisms and susceptibility to asthma: a meta-analysis.
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DOI：
10.1371/journal.pone.0053758
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Lee YH
中科院分区：
文献类型：
--
作者：
Hyun MH;Lee CH;Kang MH;Park BK;Lee YH
本研究的目的是探讨白介素10基因多态性及其单倍型是否与哮喘易感性有关。利用Medline、EMBASE和Cochrane图书馆数据库查找可用的文章。对IL-10-1082G/A、-819C/T、-592C/A基因多态性及其单倍型与哮喘的关系进行Meta分析。荟萃分析考虑了涉及2215名哮喘患者和2170名对照的11项研究。Meta分析显示IL-10-1082G等位基因与哮喘无关联[优势比(OR) = 为0.87，95%可信区间(CI) = 为0.68~1.12，p = 为0.28]。然而，根据Hardy-Weinburg平衡的Meta分析得出IL-10-1082G等位基因与哮喘的关系(OR = 为0.71，95%CI = 为0.60~0.83，p<；0.0001)。按种族分层显示，IL-10-1082G等位基因与东亚人哮喘有关联(OR = 为0.74，95%CI = 为0.57~0.96，p = 为0.02)，而在西亚人中无关联。此外，按年龄分层显示IL-10-1082G等位基因与成人和混合组哮喘的关联(OR = 为0.77，95%CI = 为0.62~0.96，p = 为0.02；OR = 为0.67，95%CI = 为0.49~0.92，p = 为0.01)。未发现哮喘与IL-10-819C/T和IL-10-592C/A基因及其单倍型相关。IL-10-1082G/A多态在东亚人和成人中增加了哮喘的易感性。但IL-10-819C/T、-592C/A基因及其单倍型与哮喘无关。
The aim of this study was to explore whether the interleukin (IL)-10 polymorphisms and their haplotypes contribute to asthma susceptibility. MEDLINE, EMBASE and the COCHRANE library databases were utilized to identify available articles. A meta-analysis was conducted on IL-10 -1082 G/A, -819 C/T, -592 C/A polymorphisms, and their haplotypes and asthma. Eleven studies involving 2,215 asthma patients and 2,170 controls were considered in the meta-analysis. The meta-analysis revealed no association between asthma and the IL-10 -1082 G allele [Odds ratio (OR) = 0.87, 95% Confidence interval (CI) = 0.68–1.12, p = 0.28]. However, meta-analysis of the five studies in Hardy-Weinburg equilibrium produced the relationship between the IL-10 -1082 G allele and asthma (OR = 0.71, 95% CI = 0.60–0.83, p<0.0001). Stratification by ethnicity indicated an association between the IL-10 -1082 G allele and asthma in East Asians (OR = 0.74, 95% CI = 0.57–0.96, p = 0.02), but not in West Asians. Furthermore, stratification by age indicated an association between the IL-10 -1082 G allele and asthma in adults and mixed groups (OR = 0.77, 95% CI = 0.62–0.96, p = 0.02; OR = 0.67, 95% CI = 0.49–0.92, p = 0.01). No association was found between asthma and IL-10 -819 C/T and IL-10 -592 C/A polymorphisms and their haplotypes. The IL-10 -1082 G/A polymorphism confers susceptibility to asthma in East Asians and in adults. However, the IL-10 -819 C/T, -592 C/A polymorphisms and their haplotypes are not associated with asthma.
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影响因子：
--
作者：
Eskdale, J;Wordsworth, P;Gallagher, G
通讯作者：
Gallagher, G
影响因子：
2.7
作者：
Hang, LW;Hsia, TC;Tsai, FJ
通讯作者：
Tsai, FJ
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
14.2
作者：
Borish, L;Aarons, A;Wenzel, S
通讯作者：
Wenzel, S
影响因子：
5
作者：
Kim, Kyung Won;Lee, Kyung Eun;Kim, Kyu-Earn
通讯作者：
Kim, Kyu-Earn