Potential role of UGT pharmacogenetics in cancer treatment and prevention: focus on tamoxifen.
Potential role of UGT pharmacogenetics in cancer treatment and prevention: focus on tamoxifen.
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DOI：
10.1111/j.1749-6632.2009.04114.x
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发表时间：
2009-02
影响因子：
5.2
通讯作者：
Sun D
中科院分区：
文献类型：
--
作者：
Lazarus P;Blevins-Primeau AS;Zheng Y;Sun D
Tamoxifen (TAM) is a selective estrogen receptor modulator that is widely used in the prevention and treatment of estrogen receptor-positive (ER+) breast cancer. Its use has significantly contributed to a decline in breast cancer mortality, since breast cancer patients treated with TAM for 5 years exhibit a 30–50% reduction in both the rate of disease recurrence after 10 years of patient follow-up and occurrence of contralateral breast cancer. However, in patients treated with TAM there is substantial interindividual variability in the development of resistance to TAM therapy, and in the incidence of TAM-induced adverse events, including deep vein thrombosis, hot flashes, and the development of endometrial cancer. This article will focus on the UDP glucuronosyltransferases, a family of metabolizing enzymes that are responsible for the deactivation and clearance of TAM and TAM metabolites, and how interindividual differences in these enzymes may play a role in patient response to TAM.
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DOI：
10.1097/00008571-199712000-00007
发表时间：
1997-12-01
期刊：
PHARMACOGENETICS
影响因子：
--
作者：
Ciotti, M;Marrone, A;Owens, IS
通讯作者：
Owens, IS
影响因子：
5.9
作者：
Bock, KW;Gschaidmeier, H;Bock-Hennig, BS
通讯作者：
Bock-Hennig, BS
DOI：
10.1093/jnci/91.19.1654
发表时间：
1999-10-06
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Bernstein, L;Deapen, D;Ford, L
通讯作者：
Ford, L
影响因子：
168.9
作者：
Bergman, L;Beelen, MLR;van Leeuwen, FE
通讯作者：
van Leeuwen, FE
DOI：
10.1124/jpet.104.065607
发表时间：
2004-09-01
影响因子：
3.5
作者：
Desta, Z;Ward, BA;Flockhart, DA
通讯作者：
Flockhart, DA