Prenatal Exposure to an EDC Mixture, NeuroMix: Effects on Brain, Behavior, and Stress Responsiveness in Rats.
Prenatal Exposure to an EDC Mixture, NeuroMix: Effects on Brain, Behavior, and Stress Responsiveness in Rats.
复制标题
DOI：
10.3390/toxics10030122
复制
发表时间：
2022-03-03
期刊：
影响因子：
4.6
通讯作者：
Thompson LM
中科院分区：
文献类型：
--
作者：
Gore AC;Moore T;Groom MJ;Thompson LM
人类和野生动物一生都会接触到干扰内分泌的化学物质（EDCs）。环境EDCs与一系列具有发育起源的疾病/障碍有关，包括神经发育和行为。edc通常是一个一个地研究；在这里，我们评估了一种混合物所引起的结果，这种混合物被设计成代表多重同时暴露的现实情况。EDCs的选择，我们称之为“NeuroMix”，是根据单一化合物研究中神经生物学效应的证据得出的，包括双酚类、邻苯二甲酸酯、vinclozolin、全氟、多溴化和多氯化合物。研究人员给怀孕的斯普拉格道利大鼠喂食了NeuroMix或载体，然后评估了雌雄后代在成年后的发育、行为和大脑基因表达方面的影响。为了确定早期EDCs是否易受出生后生活挑战的影响，一组大鼠在青春期也接受了压力挑战。产前接触NeuroMix会降低男性的体重并推迟青春期，但女性没有。成年后，NeuroMix仅在女性中引起焦虑、社交和择偶行为的改变。压力的影响主要发生在男性身上。研究发现，神经混合与应激之间存在一定的相互作用，特别是在大脑择偶行为和基因表达方面。这些发现为两种现实的环境挑战如何以性别特定的方式单独或联合导致发育和神经行为缺陷提供了新的见解。
Humans and wildlife are exposed to endocrine-disrupting chemicals (EDCs) throughout their lives. Environmental EDCs are implicated in a range of diseases/disorders with developmental origins, including neurodevelopment and behavior. EDCs are most often studied one by one; here, we assessed outcomes induced by a mixture designed to represent the real-world situation of multiple simultaneous exposures. The choice of EDCs, which we refer to as “NeuroMix,” was informed by evidence for neurobiological effects in single-compound studies and included bisphenols, phthalates, vinclozolin, and perfluorinated, polybrominated, and polychlorinated compounds. Pregnant Sprague Dawley rats were fed the NeuroMix or vehicle, and then offspring of both sexes were assessed for effects on postnatal development and behaviors and gene expression in the brain in adulthood. In order to determine whether early-life EDCs predisposed to subsequent vulnerability to postnatal life challenges, a subset of rats were also given a stress challenge in adolescence. Prenatal NeuroMix exposure decreased body weight and delayed puberty in males but not females. In adulthood, NeuroMix caused changes in anxiety-like, social, and mate preference behaviors only in females. Effects of stress were predominantly observed in males. Several interactions of NeuroMix and stress were found, especially for the mate preference behavior and gene expression in the brain. These findings provide novel insights into how two realistic environmental challenges lead to developmental and neurobehavioral deficits, both alone and in combination, in a sex-specific manner.
登录
查看更多内容
影响因子：
10.4
作者：
Crofton KM;Craft ES;Hedge JM;Gennings C;Simmons JE;Carchman RA;Carter WH Jr;DeVito MJ
通讯作者：
DeVito MJ
影响因子：
10.4
作者：
Adam N;Brusamonti L;Mhaouty-Kodja S
通讯作者：
Mhaouty-Kodja S
影响因子：
10.6
作者：
Champagne, Frances A.;Meaney, Michael J.
通讯作者：
Meaney, Michael J.
影响因子：
3.5
作者：
Gillette R;Reilly MP;Topper VY;Thompson LM;Crews D;Gore AC
通讯作者：
Gore AC
影响因子：
10.4
作者：
Dombret C;Capela D;Poissenot K;Parmentier C;Bergsten E;Pionneau C;Chardonnet S;Hardin-Pouzet H;Grange-Messent V;Keller M;Franceschini I;Mhaouty-Kodja S
通讯作者：
Mhaouty-Kodja S