A modified TNM staging system for non-metastatic colorectal cancer based on nomogram analysis of SEER database.
A modified TNM staging system for non-metastatic colorectal cancer based on nomogram analysis of SEER database.
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基于 SEER 数据库列线图分析的改良非转移性结直肠癌 TNM 分期系统
DOI：
10.1186/s12885-017-3796-1
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发表时间：
2018-01-08
期刊：
影响因子：
3.8
通讯作者：
Ding K
中科院分区：
文献类型：
--
作者：
Kong X;Li J;Cai Y;Tian Y;Chi S;Tong D;Hu Y;Yang Q;Li J;Poston G;Yuan Y;Ding K
To revise the American Joint Committee on Cancer TNM staging system for colorectal cancer (CRC) based on a nomogram analysis of Surveillance, Epidemiology, and End Results (SEER) database, and to prove the rationality of enhancing T stage’s weighting in our previously proposed T-plus staging system. Total 115,377 non-metastatic CRC patients from SEER were randomly grouped as training and testing set by ratio 1:1. The Nomo-staging system was established via three nomograms based on 1-year, 2-year and 3-year disease specific survival (DSS) Logistic regression analysis of the training set. The predictive value of Nomo-staging system for the testing set was evaluated by concordance index (c-index), likelihood ratio (L.R.) and Akaike information criteria (AIC) for 1-year, 2-year, 3-year overall survival (OS) and DSS. Kaplan–Meier survival curve was used to valuate discrimination and gradient monotonicity. And an external validation was performed on database from the Second Affiliated Hospital of Zhejiang University (SAHZU). Patients with T1-2 N1 and T1N2a were classified into stage II while T4 N0 patients were classified into stage III in Nomo-staging system. Kaplan–Meier survival curves of OS and DSS in testing set showed Nomo-staging system performed better in discrimination and gradient monotonicity, and the external validation in SAHZU database also showed distinctly better discrimination. The Nomo-staging system showed higher value in L.R. and c-index, and lower value in AIC when predicting OS and DSS in testing set. The Nomo-staging system showed better performance in prognosis prediction and the weight of lymph nodes status in prognosis prediction should be cautiously reconsidered. The online version of this article (10.1186/s12885-017-3796-1) contains supplementary material, which is available to authorized users.
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影响因子：
7.4
作者：
Galon J;Pagès F;Marincola FM;Angell HK;Thurin M;Lugli A;Zlobec I;Berger A;Bifulco C;Botti G;Tatangelo F;Britten CM;Kreiter S;Chouchane L;Delrio P;Arndt H;Asslaber M;Maio M;Masucci GV;Mihm M;Vidal-Vanaclocha F;Allison JP;Gnjatic S;Hakansson L;Huber C;Singh-Jasuja H;Ottensmeier C;Zwierzina H;Laghi L;Grizzi F;Ohashi PS;Shaw PA;Clarke BA;Wouters BG;Kawakami Y;Hazama S;Okuno K;Wang E;O'Donnell-Tormey J;Lagorce C;Pawelec G;Nishimura MI;Hawkins R;Lapointe R;Lundqvist A;Khleif SN;Ogino S;Gibbs P;Waring P;Sato N;Torigoe T;Itoh K;Patel PS;Shukla SN;Palmqvist R;Nagtegaal ID;Wang Y;D'Arrigo C;Kopetz S;Sinicrope FA;Trinchieri G;Gajewski TF;Ascierto PA;Fox BA
通讯作者：
Fox BA
影响因子：
1.6
作者：
Li J;Yi CH;Hu YT;Li JS;Yuan Y;Zhang SZ;Zheng S;Ding KF
通讯作者：
Ding KF
验证纪念斯隆-凯特琳癌症中心诺模图预测中国结肠癌人群治愈性结肠切除术后的总体生存率
影响因子：
3.7
作者：
Liu, Maoxing;Qu, Hong;Su, Xiangqian
通讯作者：
Su, Xiangqian
DOI：
10.1016/s1470-2045(14)71116-7
发表时间：
2015-04
期刊：
The Lancet. Oncology
影响因子：
--
作者：
Balachandran VP;Gonen M;Smith JJ;DeMatteo RP
通讯作者：
DeMatteo RP
DOI：
10.1097/pas.0000000000000320
发表时间：
2015-01
期刊：
The American journal of surgical pathology
影响因子：
--
作者：
Jin M;Roth R;Rock JB;Washington MK;Lehman A;Frankel WL
通讯作者：
Frankel WL