Clinical features and management of cytomegalovirus corneal endotheliitis: analysis of 106 cases from the Japan corneal endotheliitis study.
Clinical features and management of cytomegalovirus corneal endotheliitis: analysis of 106 cases from the Japan corneal endotheliitis study.
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DOI：
10.1136/bjophthalmol-2013-304625
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发表时间：
2015-01
期刊：
影响因子：
--
通讯作者：
Japan Corneal Endotheliitis Study Group
中科院分区：
文献类型：
--
作者：
Koizumi N;Inatomi T;Suzuki T;Shiraishi A;Ohashi Y;Kandori M;Miyazaki D;Inoue Y;Soma T;Nishida K;Takase H;Sugita S;Mochizuki M;Kinoshita S;Japan Corneal Endotheliitis Study Group
本研究的目的是通过在日本进行的一项全国性调查中获得的大量病例系列来阐明巨细胞病毒（CMV）内皮炎的临床表现和治疗现状。日本角膜内皮炎研究组提出了巨细胞病毒内皮炎的诊断标准，基于水体液PCR病毒检测，并结合临床表现。随后对日本角膜协会的1160名成员进行了一项全国性的回顾性调查。该研究回顾了符合巨细胞病毒内皮炎诊断标准的患者概况、临床表现和治疗方式。这项研究包括106名患者的109只眼睛。患者平均年龄66.9±10.9岁（男性85例（80.2%），女性21例（19.8%））。在确认巨细胞病毒内皮炎之前，患者通常被诊断为前葡萄膜炎和高眼压。硬币状病变占70.6%，线状角膜沉淀占8.3%。95%的病例接受抗巨细胞病毒药物治疗。巨细胞病毒内皮炎最常见于中老年男性。当患者出现硬币状角膜内皮炎并伴有前葡萄膜炎和高眼压时，应怀疑巨细胞病毒内皮炎。
The purpose of this study is to elucidate the clinical manifestations and the current treatment status of cytomegalovirus (CMV) endotheliitis via a large case series obtained from a national survey conducted in Japan. The Japan Corneal Endotheliitis Study Group proposed diagnostic criteria for CMV endotheliitis based on a viral examination by PCR of aqueous humour, in combination with clinical manifestations. A national survey was then retrospectively conducted among 1160 members of the Japan Cornea Society. The study reviewed the patient profiles, clinical manifestations, and treatment modalities of individuals who met the diagnostic criteria for CMV endotheliitis. The study included 109 eyes of 106 patients. Mean patient age was 66.9±10.9 years (85 males (80.2%), 21 females (19.8%)). Patients were commonly diagnosed with anterior uveitis and ocular hypertension prior to confirmation of CMV endotheliitis. Coin-shaped lesions were observed in 70.6%, and linear keratic precipitates in 8.3% of the patients, respectively. 95% of cases were treated with anti-CMV drugs. CMV endotheliitis is most common in middle-aged and elderly men. CMV endotheliitis should be suspected when patients present with corneal endotheliitis involving coin-shaped lesions accompanied by anterior uveitis and ocular hypertension.
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影响因子：
4.2
作者：
Shiraishi, Atsushi;Hara, Yuko;Ohashi, Yuichi
通讯作者：
Ohashi, Yuichi
影响因子：
2.8
作者：
Suzuki, Takashi;Hara, Yuko;Ohashi, Yuichi
通讯作者：
Ohashi, Yuichi
DOI：
10.1007/s00417-010-1510-y
发表时间：
2011-01-01
影响因子：
2.7
作者：
Hwang, Yih-Shiou;Shen, Chia-Rui;Hsiao, Ching-Hsi
通讯作者：
Hsiao, Ching-Hsi
影响因子：
13.7
作者：
Kandori, Michiko;Inoue, Tomoyuki;Tano, Yasuo
通讯作者：
Tano, Yasuo
影响因子：
13.7
作者：
Koizumi, Noriko;Suzuki, Takashi;Kinoshita, Shigeru
通讯作者：
Kinoshita, Shigeru