Viruses and multiple sclerosis.
Viruses and multiple sclerosis.
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DOI：
10.1177/1073858411386615
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发表时间：
2011-12
期刊：
影响因子：
--
通讯作者：
Bennett JL
中科院分区：
文献类型：
--
作者：
Owens GP;Gilden D;Burgoon MP;Yu X;Bennett JL
多发性硬化（MS）是一种病因不明的慢性脱髓鞘疾病，可能由病毒或病毒触发的免疫病理学引起。病毒可能在潜伏数年后重新激活并溶解少突胶质细胞，如进行性多灶性白质脑病，或启动免疫病理性脱髓鞘，如感染泰勒鼠脑脊髓炎病毒或冠状病毒的动物。MS的病毒原因的论点得到了流行病学分析和同卵双胞胎MS研究的支持，表明疾病是获得性的。然而，最重要的证据是MS脑和CSF中存在寡克隆IgG（OCB）条带，这些条带在患者的一生中持续存在。OCB几乎仅在感染性CNS疾病中发现，并且OCB的抗原靶标代表引起疾病的因子。在这里，作者回顾了过去的尝试，以确定感染剂在MS脑细胞和讨论的承诺，使用重组抗体产生的克隆扩增浆细胞在脑和CSF中，以确定疾病相关抗原。他们展示了这种策略如何成功地用于分析亚急性硬化性全脑炎（一种由麻疹病毒引起的慢性脑炎）和视神经肌病（一种由针对水通道蛋白-4水通道的抗体产生的慢性自身免疫性脱髓鞘疾病）的抗原特异性。
Multiple sclerosis (MS) is a chronic demyelinating disorder of unknown etiology, possibly caused by a virus or virus-triggered immunopathology. The virus might reactivate after years of latency and lyse oligodendrocytes, as in progressive multifocal leukoencephalopathy, or initiate immunopathological demyelination, as in animals infected with Theiler’s murine encephalomyelitis virus or coronaviruses. The argument for a viral cause of MS is supported by epidemiological analyses and studies of MS in identical twins, indicating that disease is acquired. However, the most important evidence is the presence of bands of oligoclonal IgG (OCBs) in MS brain and CSF that persist throughout the lifetime of the patient. OCBs are found almost exclusively in infectious CNS disorders, and antigenic targets of OCBs represent the agent that causes disease. Here, the authors review past attempts to identify an infectious agent in MS brain cells and discuss the promise of using recombinant antibodies generated from clonally expanded plasma cells in brain and CSF to identify disease-relevant antigens. They show how this strategy has been used successfully to analyze antigen specificity in subacute sclerosing panencephalitis, a chronic encephalitis caused by measles virus, and in neuromyelitis optica, a chronic autoimmune demyelinating disease produced by antibodies directed against the aquaporin-4 water channel.
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影响因子：
11.2
作者：
Bennett, Jeffrey L.;Lam, Chiwah;Kalluri, Sudhakar Reddy;Saikali, Philippe;Bautista, Katherine;Dupree, Cecily;Glogowska, Magdalena;Case, David;Antel, Jack P.;Owens, Gregory P.;Gilden, Don;Nessler, Stefan;Stadelmann, Christine;Hemmer, Bernhard
通讯作者：
Hemmer, Bernhard
DOI：
10.1073/pnas.0502323102
发表时间：
2005-05-17
影响因子：
11.1
作者：
Burgoon, MP;Keays, KM;Gilden, DH
通讯作者：
Gilden, DH
影响因子：
11.2
作者：
Breij, Esther C. W.;Brink, Bianca P.;Boe, Lars
通讯作者：
Boe, Lars
影响因子：
15.9
作者：
Cepok, S;Zhou, D;Hemmer, B
通讯作者：
Hemmer, B
影响因子：
3.2
作者：
Burgoon, Mark P.;Caldas, Yupanqui A.;Owens, Gregory P.
通讯作者：
Owens, Gregory P.