Tissue reaction to orthodontic tooth movement in different bone turnover conditions.
Tissue reaction to orthodontic tooth movement in different bone turnover conditions.
复制标题
不同骨转换条件下正畸牙齿移动的组织反应。
DOI：
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发表时间：
2003
影响因子：
3.1
通讯作者：
B. Melsen
中科院分区：
文献类型：
--
作者：
C. Verna;B. Melsen
目标
研究正常、高、低骨转换状态下正畸载荷对组织的影响。
设计
“裂口”设计进行正畸牙齿移动在52个，6个月大的雄性大鼠：正常（n = 19），高（n = 16），和低骨转换（n = 17），后两个是通过诱导甲状腺功能亢进症和甲状腺功能减退症，分别获得。在奥胡斯大学正畸系进行。
实验变量
左上第一磨牙移动21天。在处死前7天和2天给予骨标记物。在冠状和顶端水平切割组织切片。
结局指标
测量并比较三组患者的牙槽窝面积、牙周膜宽度、牙槽窝壁与侵蚀面的相对延伸度、矿化面。
结果
三组患者治疗侧牙槽窝、牙周膜宽度及糜烂面均大于对照侧。正常组和甲状腺功能减退组在冠状面的颊远侧牙周膜较宽，而甲状腺功能亢进组的牙周膜增宽不具有空间方向性。正常组和甲亢组在冠状-正中部位表现出更高的侵蚀。正常组和甲状腺功能减退组治疗侧的矿化表面大于对照侧，但甲状腺功能亢进组的矿化表面没有变化。
结论
在甲亢组中，牙周膜的增宽不是空间定向的，并且增加的侵蚀并不伴随着增加的形成，如在正常组和甲状腺功能减退组中观察到的。
OBJECTIVES
To study the tissue reaction to orthodontic load in normal, high, and low bone turnover states.
DESIGN
'Split mouth' design performing orthodontic tooth movement in 52, 6-month-old male rats with: normal (n = 19), high (n = 16), and low bone turnover (n = 17), the latter two being obtained by induction of hyperthyroidism and hypothyroidism, respectively. Performed at the Department of Orthodontics at Aarhus University.
EXPERIMENTAL VARIABLE
The upper left first molar was moved for 21 days. Bone markers were administered 7 and 2 days before killing. Histological sections were cut at the coronal and apical levels.
OUTCOME MEASURE
Alveolar socket area, periodontal ligament width, the relative extension of alveolar wall with erosion surfaces, and the mineralizing surfaces were measured and compared in the three groups.
RESULTS
Alveolar socket, periodontal ligament width, and erosion surface were larger on the treated than on the control side in the three groups. The normal and hypothyroid groups showed a wider periodontal ligament at the bucco-distal site at the coronal level, while the hyperthyroid group showed a widening which was not spatially oriented. The normal and hyperthyroid groups showed higher erosion at the corono-mesial site. The mineralizing surfaces were larger on the treated than on the control side in the normal and hypothyroid groups, but not in the hyperthyroid group.
CONCLUSION
In the hyperthyroid group, the widening of the periodontal ligament was not spatially oriented and the increased erosion was not accompanied by increased formation, as observed in the normal and hypothyroid groups.
影响因子：
4.1
作者：
KING, GJ;KEELING, SD;WRONSKI, TJ
通讯作者：
WRONSKI, TJ