Food insufficiency is a risk factor for suboptimal antiretroviral therapy adherence among HIV-infected adults in urban Peru.

Food insufficiency is a risk factor for suboptimal antiretroviral therapy adherence among HIV-infected adults in urban Peru.
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DOI:
10.1007/s10461-010-9789-6
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发表时间:
2011-10
期刊:
影响因子:
4.4
通讯作者:
Shin, Sonya S.
Shin, Sonya S.
中科院分区:
医学2区
文献类型:
--
作者:
Franke, Molly F.;Murray, Megan B.;Munoz, Maribel;Hernandez-Diaz, Sonia;Luis Sebastian, Jose;Atwood, Sidney;Caldas, Adolfo;Bayona, Jaime;Shin, Sonya S.

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我们研究了食物不足与抗逆转录病毒治疗(ART)依从性之间的关系。在开始抗逆转录病毒治疗后,对秘鲁城市一组感染艾滋病毒的成年人进行了为期两年的随访。使用30天自我报告工具测量ART依从性,如果报告的依从性<95%,则归类为次优。我们进行了一项重复测量队列分析,以检查食物不足是否在次优依从的月份相对于最佳依从的月份更常见。对134人进行了1264次依从性访谈。在访谈前一个月报告食物不足的参与者比那些没有食物不足的参与者更有可能经历次优依从性(优势比[O.R.]:2.4; 95%可信区间[C.I.]:1.4, 4.1),即使在调整了基线社会支持评分(O.R.每增加5分:0.91;C.I.:[0.85, 0.98])和良好的基线依从性自我效能(O.R.:0.25; C.I.:[0.09, 0.69])之后也是如此。确保艾滋病毒感染者粮食安全的干预措施可能有助于维持高水平的依从性。
We examined the relationship between food insufficiency and antiretroviral therapy (ART) adherence. A cohort of HIV-infected adults in urban Peru was followed for a two-year period after ART initiation. ART adherence was measured using a 30-day self-report tool and classified as suboptimal if <95% adherence was reported. We conducted a repeated measures cohort analysis to examine whether food insufficiency was more common during months of suboptimal adherence relative to months with optimal adherence. 1,264 adherence interviews were conducted for 134 individuals. Participants who reported food insufficiency in the month prior to interview were more likely to experience suboptimal adherence than those who did not (odds ratio [O.R.]:2.4; 95% confidence interval [C.I.]:1.4, 4.1), even after adjusting for baseline social support score (O.R. per 5 point increase:0.91; C.I.:[0.85, 0.98]) and good baseline adherence self-efficacy (O.R.:0.25; C.I.:[0.09, 0.69]). Interventions that ensure food security for HIV-infected individuals may help sustain high levels of adherence.
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