Pigment-Dispersing Hormone Shifts the Phase of the Circadian Pacemaker of the Cockroach Leucophaea maderae
Pigment-Dispersing Hormone Shifts the Phase of the Circadian Pacemaker of the Cockroach Leucophaea maderae
复制标题
色素分散激素改变蟑螂 Leucophaea maderae 昼夜节律起搏器的相位
作者：
B. Petri;M. Stengl
抗甲壳类神经肽色素分散激素的抗血清染色的几个半变态和全变态昆虫的视叶的一小部分神经元。这些细胞的主要分支位于视叶的副髓质中，它们满足生物钟神经元的几个预测标准。例如，在果蝇中，它们表达时间和周期，这是昼夜节律起搏器的两个分子组成部分。为了测试色素分散激素是否在蟑螂Leucophaea maderae中实现昼夜节律功能，将150 fmol的合成肽注射到副髓质附近。这导致了一个稳定的相位依赖性重置的昼夜运动活动节律的相位，这取决于色素分散激素的注射量。由此产生的相位响应曲线与光脉冲所获得的不同，这表明分散色素的神经元不是起搏器的视觉输入通路的一部分，而是其不可分割的一部分和/或进入时钟的非光输入的一部分。一个可能的作用，这些神经元耦合双边配对的昼夜节律起搏器进行了讨论。
An antiserum against the crustacean neuropeptide pigment-dispersing hormone stains a small set of neurons in the optic lobes of several hemimetabolous and holometabolous insects. These cells, the primary branches of which in the optic lobe lie in the accessory medulla, fulfill several criteria predicted for neurons of the circadian clock. For example, in fruit flies they express timeless andperiod, which are two molecular components of the circadian pacemaker. To test whether pigment-dispersing hormone fulfills a circadian function in the cockroach Leucophaea maderae, 150 fmol of synthetic peptide was injected into the vicinity of the accessory medulla. This resulted in a stable phase-dependent resetting of the phase of the circadian locomotor activity rhythm, which depended on the amount of pigment-dispersing hormone injected. The resulting phase–response curve differs from that obtained with light pulses, suggesting that pigment-dispersing hormone-immunoreactive neurons are not part of the visual input pathway to the pacemaker but an integral part of it and/or part of a nonphotic input into the clock. A possible role of these neurons in coupling the bilaterally paired circadian pacemakers is discussed.
影响因子：
56.9
作者：
MICHEL, S;GEUSZ, ME;BLOCK, GD
通讯作者：
BLOCK, GD
局部低温脉冲对蟑螂昼夜节律起搏器的影响。
DOI：
10.1152/ajpregu.1981.240.3.r144
发表时间：
1981
期刊：
The American journal of physiology
影响因子：
--
作者：
Page,TL
通讯作者：
Page,TL