Congenital dyserythropoiesis and polymyopathy without cardiac disease in male Labrador retriever littermates.
Congenital dyserythropoiesis and polymyopathy without cardiac disease in male Labrador retriever littermates.
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DOI：
10.1111/jvim.16214
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发表时间：
2021-09
影响因子：
2.6
通讯作者：
Walsh KA
中科院分区：
文献类型：
--
作者：
Thomas-Hollands A;Shelton GD;Guo LT;Loughran K;Kaiman G;A Hutton T;Walsh KA
根据偶然发现的显著小红细胞增多和不适当的红细胞增多，确定了两只拉布拉多猎犬同窝仔。在研究的1只犬的活检样本中观察到肌肉萎缩，并与独特的病理学结果相关。这种疾病是一种罕见的疑似先天性红细胞生成障碍和多肌病的临床实体。临床病理学变化与先前报道的3只相关英国史宾格犬（ESS）先天性红细胞生成障碍、先天性多肌病和心脏病综合征相似，但本文报道的犬没有明显的心脏病。对犬1进行骨髓抽吸、肌电图、肌肉活检和超声心动图检查。结果支持红细胞生成障碍和先天性多肌病，类似于ESS犬的报告，但没有发现明显的心脏疾病。红细胞生成不良和多肌病的临床病理变化为低发病率综合征提供了一个容易识别的表型。早期识别可以减少不必要的测试或安乐死。
Two Labrador retriever littermates were identified based on incidentally noted marked microcytosis and inappropriate metarubricytosis. Muscle atrophy was noted and associated with distinctive pathological findings in biopsy samples from 1 dog studied. The disorder represents a rare clinical entity of suspected congenital dyserythropoiesis and polymyopathy. Clinicopathologic changes were similar to a previously reported syndrome of congenital dyserythropoiesis, congenital polymyopathy, and cardiac disease in 3 related English Springer Spaniel (ESS) dogs, but the dogs reported here did not have apparent cardiac disease. Bone marrow aspiration, electromyography, muscle biopsies, and an echocardiogram were performed on dog 1. Results supported dyserythropoiesis and congenital polymyopathy similar to reports in ESS dogs, but did not identify obvious cardiac disease. The clinicopathologic changes of dyserythropoiesis and polymyopathy provide an easily recognizable phenotype for what appears to be a low morbidity syndrome. Early recognition may decrease unnecessary testing or euthanasia.
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影响因子：
3.7
作者：
Maurer M;Mary J;Guillaud L;Fender M;Pelé M;Bilzer T;Olby N;Penderis J;Shelton GD;Panthier JJ;Thibaud JL;Barthélémy I;Aubin-Houzelstein G;Blot S;Hitte C;Tiret L
通讯作者：
Tiret L
影响因子：
20.3
作者：
Iolascon, Achille;Heimpel, Hermann;Tamary, Hannah
通讯作者：
Tamary, Hannah
影响因子：
4.5
作者：
Boehm, Johann;Vasli, Nasim;Laporte, Jocelyn
通讯作者：
Laporte, Jocelyn
DOI：
10.1111/j.1939-1676.1998.tb02145.x
发表时间：
1998-11-01
影响因子：
2.6
作者：
Delauche, AJ;Cuddon, PA;Shelton, GD
通讯作者：
Shelton, GD
DOI：
10.1111/j.1939-1676.1991.tb00942.x
发表时间：
1991-05-01
影响因子：
2.6
作者：
HOLLAND, CT;CANFIELD, PJ;ALLAN, GS
通讯作者：
ALLAN, GS