CMV infection, TLR-2 and -4 expression, and cytokine profiles in early-onset preeclampsia with HELLP syndrome.
CMV infection, TLR-2 and -4 expression, and cytokine profiles in early-onset preeclampsia with HELLP syndrome.
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DOI：
10.1111/aji.12199
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发表时间：
2014-04
期刊：
影响因子：
--
通讯作者：
Nadeau J
中科院分区：
文献类型：
--
作者：
Xie F;von Dadelszen P;Nadeau J
巨细胞病毒（CMV）感染曾在妊娠并发症中有报道。然而，其血清阳性率和相关toll样受体（TLR）在早发性子痫前期（EOPE）伴溶血、肝酶升高和低血小板综合征（helps）中的表达尚不清楚。本研究采用病例对照研究的方法，检测孕妇巨细胞病毒抗体、中性粒细胞Toll样受体(TLR)-2和-4的表达以及细胞因子在EOPE合并helps (EOPE- helps) （n=10）、晚发型子痫前期（LOPE） （n=20）、正常妊娠（n=60）和非妊娠（n=20）对照中的表达。与配对的正常和非妊娠对照组相比，eope - helps显著提高CMV IgG血清阳性，上调TLR-2/- 4mrna表达，升高血清IL-6和TNF-α，降低IL-10。LOPE与正常妊娠对照组无显著差异。我们观察到在eope - helps中巨细胞病毒感染和先天免疫应答有显著的关联。我们的数据表明巨细胞病毒感染可能是这种疾病的一个危险因素。
Cytomegalovirus (CMV) infection was previously reported in pregnancy complications. However, its seroprevalence and associated Toll-like receptor (TLR) expression in early onset preeclampsia (EOPE) with Hemolysis, Elevated Liver enzyme and Low Platelets syndrome (HELLPs) are unexplored. A case-control study was performed to examine maternal CMV antibodies, neutrophil Toll like receptor (TLR)-2 and -4 expression as well as the cytokine profile in EOPE with HELLPs (EOPE-HELLPs) (n=10), late onset preeclampsia (LOPE) (n=20), normal pregnancy (n=60), and non-pregnancy (n=20) controls. EOPE-HELLPs had significantly increased CMV IgG sero-positivity, up-regulated TLR-2/-4 mRNA expression, elevated serum IL-6 and TNF-α, and reduced IL-10 compared with matched normal and non-pregnancy controls. No significant difference was observed between LOPE and normal pregnancy controls. We observed a significant association of CMV infection and innate immune response in EOPE-HELLPs. Our data suggest CMV infection may be a risk factor for this disorder.
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