Structural remodeling of astrocytes in the injured CNS.
Structural remodeling of astrocytes in the injured CNS.
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DOI：
10.1177/1073858411423441
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发表时间：
2012-12
期刊：
影响因子：
--
通讯作者：
Jakobs TC
中科院分区：
文献类型：
--
作者：
Sun D;Jakobs TC
星形胶质细胞通过变得反应性来应对所有形式的中枢神经系统损伤和疾病，这是一种非特异性但高度特征性的反应，涉及各种形态和分子变化。反应性星形胶质细胞最受认可的方面可能是阻碍轴突再生的神经胶质疤痕的形成。尽管反应表型在 100 多年前首次根据形态变化提出，但其重塑过程尚不清楚。我们对反应性星形胶质细胞的实际结构、星形胶质细胞在损伤过程中如何重塑以及这些细胞群如何重组形成神经胶质疤痕知之甚少。标记星形胶质细胞的新方法以及转基因小鼠使反应性星形胶质细胞的完整形态得以可视化。最近的研究表明，反应性可以引起单个星形胶质细胞形状的显着变化，并非所有星形胶质细胞都以相同的方式反应，并且反应性反应具有可塑性。
Astrocytes respond to all forms of CNS insult and disease by becoming reactive, a nonspecific but highly characteristic response that involves various morphological and molecular changes. Probably the most recognized aspect of reactive astrocytes is the formation of a glial scar that impedes axon regeneration. Although the reactive phenotype was first suggested more than 100 years ago based on morphological changes, the remodeling process is not well understood. We know little about the actual structure of a reactive astrocyte, how an astrocyte remodels during the progression of an insult, and how populations of these cells reorganize to form the glial scar. New methods of labeling astrocytes, along with transgenic mice, allow the complete morphology of reactive astrocytes to be visualized. Recent studies show that reactivity can induce a remarkable change in the shape of a single astrocyte, that not all astrocytes react in the same way, and that there is plasticity in the reactive response.
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影响因子：
3.4
作者：
CHVATAL, A;PASTOR, A;KETTENMANN, H
通讯作者：
KETTENMANN, H
影响因子：
5.3
作者：
Bushong, EA;Martone, ME;Ellisman, MH
通讯作者：
Ellisman, MH
影响因子：
25
作者：
Bezzi, P;Gundersen, V;Volterra, A
通讯作者：
Volterra, A
影响因子：
4.2
作者：
Benesova, Jana;Hock, Miroslav;Chvatal, Alexander
通讯作者：
Chvatal, Alexander
DOI：
10.1007/bf02284808
发表时间：
1996-06-01
期刊：
JOURNAL OF NEUROCYTOLOGY
影响因子：
--
作者：
Butt, AM;Colquhoun, K
通讯作者：
Colquhoun, K