A cluster analysis of tic symptoms in children and adults with Tourette syndrome: clinical correlates and treatment outcome.
A cluster analysis of tic symptoms in children and adults with Tourette syndrome: clinical correlates and treatment outcome.
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DOI：
10.1016/j.psychres.2013.09.021
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发表时间：
2013-12-30
影响因子：
11.3
通讯作者：
Scahill L
中科院分区：
文献类型：
--
作者：
McGuire JF;Nyirabahizi E;Kircanski K;Piacentini J;Peterson AL;Woods DW;Wilhelm S;Walkup JT;Scahill L
聚类分析方法已经研究了慢性抽动障碍（CTD）的症状表现，在研究中的一致性有限。本研究调查了抽动症状的模式、临床相关性和治疗结果。239名患有CTD的青少年和成人在基线时完成了一系列评估，以确定诊断，抽搐严重程度和临床特征。参与者被随机分配接受抽搐综合行为干预（CBIT）或心理教育和支持治疗（PST）。对基线耶鲁整体抽动严重程度量表（YGTSS）症状检查表进行聚类分析，以确定抽动症状的星座。四个抽搐集群被确定为：冲动控制和复杂的语音抽搐;复杂的运动抽搐;简单的头部运动/声乐抽搐;和Primendary简单的运动抽搐。青少年和成年人的抽搐症状频率几乎没有差异。抽搐簇与临床特征有小的关联，与共存的精神疾病的存在没有关联。聚类隶属度评分不能预测CBIT治疗反应或抽动严重程度降低。抽动症状明显地聚集在一起，在青年和成年人之间或共存条件下几乎没有差异。这项研究，这是第一个检查抽搐集群与治疗的关系，表明抽搐症状的轮廓同样很好地响应CBIT。
Cluster analytic methods have examined the symptom presentation of chronic tic disorders (CTDs), with limited agreement across studies. The present study investigated patterns, clinical correlates, and treatment outcome of tic symptoms. 239 youth and adults with CTDs completed a battery of assessments at baseline to determine diagnoses, tic severity, and clinical characteristics. Participants were randomly assigned to receive either a comprehensive behavioral intervention for tics (CBIT) or psychoeducation and supportive therapy (PST). A cluster analysis was conducted on the baseline Yale Global Tic Severity Scale (YGTSS) symptom checklist to identify the constellations of tic symptoms. Four tic clusters were identified: Impulse Control and Complex Phonic Tics; Complex Motor Tics; Simple Head Motor/Vocal Tics; and Primarily Simple Motor Tics. Frequencies of tic symptoms showed few differences across youth and adults. Tic clusters had small associations with clinical characteristics and showed no associations to the presence of coexisting psychiatric conditions. Cluster membership scores did not predict treatment response to CBIT or tic severity reductions. Tic symptoms distinctly cluster with few difference across youth and adults, or coexisting conditions. This study, which is the first to examine tic clusters in relation to treatment, suggested that tic symptom profiles respond equally well to CBIT.
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影响因子：
6.4
作者：
Kraft, Janne Tabori;Dalsgaard, Soren;Scahill, Lawrence
通讯作者：
Scahill, Lawrence
影响因子：
3.9
作者：
BORGEN, FH;BARNETT, DC
通讯作者：
BARNETT, DC
影响因子：
3.6
作者：
Storch, EA;Murphy, TK;Goodman, WK
通讯作者：
Goodman, WK
影响因子：
3.6
作者：
Kircanski K;Woods DW;Chang SW;Ricketts EJ;Piacentini JC
通讯作者：
Piacentini JC
影响因子：
1.8
作者：
Specht, Matt W.;Woods, Douglas W.;Piacentini, John;Scahill, Lawrence;Wilhelm, Sabine;Peterson, Alan L.;Chang, Susanna;Kepley, Hayden;Deckersbach, Thilo;Flessner, Christopher;Buzzella, Brian A.;McGuire, Joseph F.;Levi-Pearl, Sue;Walkup, John T.
通讯作者：
Walkup, John T.