Molecular mechanisms of homeostatic synaptic downscaling.
Molecular mechanisms of homeostatic synaptic downscaling.
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DOI：
10.1016/j.neuropharm.2013.07.009
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发表时间：
2014-03
影响因子：
4.7
通讯作者：
Xia H
中科院分区：
文献类型：
--
作者：
Siddoway B;Hou H;Xia H
动态平衡突触下调是对慢性升高的网络活动的负反馈反应，以降低神经元的放电率。这种形式的突触可塑性会将单个突触的强度降低到相同的比例，或者以一种相乘的方式。正因为如此，突触缩小尺度被认为是为了对抗Hebbian型长时程增强(LTP)引起的潜在失控兴奋，同时保留在单个突触中编码的相对突触重量，从而保留记忆信息。在这篇文章中，我们将对突触下调的信号和分子机制的现有知识进行综述。具体地说，我们主要关注三个方面。首先讨论了几个即刻早期基因如PLK2、Hmer 1a、Arc和Narp的功能作用。其次，我们考察了目前关于通过泛素化和转录抑制来调节突触蛋白水平的知识。第三，我们回顾了信号分子的动力学，如对突触缩小至关重要的激酶和磷酸酶，以及它们对突触支架蛋白的调节。最后，我们简要讨论了自稳突触降尺度机制的异质性。本文是《动态平衡突触可塑性》特刊的一部分。
Homeostatic synaptic downscaling is a negative feedback response to chronic elevated network activity to reduce the firing rate of neurons. This form of synaptic plasticity decreases the strength of individual synapses to the same proportion, or in a multiplicative manner. Because of this, synaptic downscaling has been hypothesized to counter the potential run-away excitation due to Hebbian type of long term potentiation (LTP), while preserving relative synaptic weight encoded in individual synapses and thus memory information. In this article, we will review the current knowledge on the signaling and molecular mechanisms of synaptic downscaling. Specifically, we focus on three general areas. First the functional roles of several immediate early genes such as Plk2, Homer1a, Arc and Narp are discussed. Secondly, we examine the current knowledge on the regulation of synaptic protein levels by ubiquitination and transcriptional repression in synaptic downscaling. Thirdly, we review the dynamics of signaling molecules such as kinases and phosphatases critical for synaptic downscaling, and their regulation of synaptic scaffolding proteins. Finally we briefly discuss the heterogeneity of homeostatic synaptic downscaling mechanisms. This article is part of the Special Issue entitled ‘Homeostatic Synaptic Plasticity’.
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通过光控制的单突触激活对AMPA受体运输和降解的稳态调节。
影响因子：
16.2
作者：
Hou Q;Gilbert J;Man HY
通讯作者：
Man HY
影响因子：
25
作者：
Chang, Michael C.;Park, Joo Min;Pelkey, Kenneth A.;Grabenstatter, Heidi L.;Xu, Desheng;Linden, David J.;Sutula, Thomas P.;McBain, Chris J.;Worley, Paul F.
通讯作者：
Worley, Paul F.
DOI：
10.1523/jneurosci.4427-11.2012
发表时间：
2012-04-11
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Djakovic SN;Marquez-Lona EM;Jakawich SK;Wright R;Chu C;Sutton MA;Patrick GN
通讯作者：
Patrick GN
影响因子：
5.3
作者：
Hayashi, T;Huganir, RL
通讯作者：
Huganir, RL
影响因子：
16.2
作者：
Chowdhury, Shoaib;Shepherd, Jason D.;Worley, Paul F.
通讯作者：
Worley, Paul F.