Mild cognitive impairment in long-term brain tumor survivors following brain irradiation.
Mild cognitive impairment in long-term brain tumor survivors following brain irradiation.
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DOI：
10.1007/s11060-018-03032-8
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发表时间：
2019-01
影响因子：
3.9
通讯作者：
Rapp SR
中科院分区：
文献类型：
--
作者：
Cramer CK;McKee N;Case LD;Chan MD;Cummings TL;Lesser GJ;Shaw EG;Rapp SR
癌症幸存者的认知障碍没有一个公认的分类。我们使用改编自国家老龄研究所和阿尔茨海默氏症协会(NIA-AA)的标准来评估脑瘤幸存者的轻度认知障碍(MCI)综合征的程度。我们回顾了2008-2011年在多奈哌齐和安慰剂治疗认知障碍的随机试验中，接受放射治疗(RT)后脑瘤幸存者的认知数据。在美国的24个地点招募了198名患有原发或转移性脑瘤的成年幸存者，他们在放疗后6个月进行了≥。在随机分组后的基线、12周和24周进行认知功能评估。在这项分析中，我们使用基线数据，使用调整后的NIA-AA标准来确定MCI和可能的痴呆症。将病例分为4组：遗忘型MCI-单域(aMCI-SD)、遗忘型MCI-多域(aMCI-MD)、非遗忘型MCI-单域(NAMCI-SD)和非遗忘型MCI-多域(NAMCI-MD)。131名可评估的患者(66%)符合微循环损伤的标准。其中aMCI-SD占13%，aMCI-MD占58%，NAMCI-SD占19%，NAMCI-MD占10%。表现状况较差、受教育程度较低、家庭收入较低以及不外出工作的患者更有可能被归类为MCI。三分之二的放疗后脑瘤幸存者符合NIA-AA的MCI标准。当应用于脑瘤幸存者时，这种分类可能是有用的，因为它定义了认知表型，这些表型可能与病程、治疗反应和风险因素特征有不同的关联。
There is no accepted classification of cognitive impairment in cancer survivors. We assess the extent of mild cognitive impairment (MCI) syndrome in brain tumor survivors using criteria adapted from the National Institute on Aging and the Alzheimer’s Association (NIA-AA). We retrospectively reviewed the cognitive data of brain tumor survivors post-radiation therapy (RT) enrolled from 2008 to 2011 in a randomized trial of donepezil versus placebo for cognitive impairment. One hundred and ninety eight adult survivors with primary or metastatic brain tumors who were ≥ 6 months post RT were recruited at 24 sites in the United States. Cognitive function was assessed at baseline, 12 and 24 weeks post-randomization. For this analysis, we used baseline data to identify MCI and possible dementia using adapted NIA-AA criteria. Cases were subtyped into four groups: amnestic MCI-single domain (aMCI-sd), amnestic MCI-multiple domain (aMCI-md), non-amnestic MCI-single domain (naMCI-sd), and non-amnestic MCI-multiple domain (naMCI-md). One hundred and thirty one of 197 evaluable patients (66%) met criteria for MCI. Of these, 13% were classified as aMCI-sd, 58% as aMCI-md, 19% as naMCI-sd, and 10% as naMCI-md. Patients with poorer performance status, less education, lower household income and those not working outside the home were more likely to be classified as MCI. Two-thirds of post-RT brain tumor survivors met NIA-AA criteria for MCI. This taxonomy may be useful when applied to brain tumor survivors because it defines cognitive phenotypes that may be differentially associated with course, treatment response, and risk factor profiles.
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影响因子：
2.3
作者：
Okoukoni C;McTyre ER;Ayala Peacock DN;Peiffer AM;Strowd R;Cramer C;Hinson WH;Rapp S;Metheny-Barlow L;Shaw EG;Chan MD
通讯作者：
Chan MD
DOI：
10.1016/j.jalz.2011.03.005
发表时间：
2011-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
McKhann GM;Knopman DS;Chertkow H;Hyman BT;Jack CR Jr;Kawas CH;Klunk WE;Koroshetz WJ;Manly JJ;Mayeux R;Mohs RC;Morris JC;Rossor MN;Scheltens P;Carrillo MC;Thies B;Weintraub S;Phelps CH
通讯作者：
Phelps CH
影响因子：
4.7
作者：
Greene-Schloesser D;Robbins ME;Peiffer AM;Shaw EG;Wheeler KT;Chan MD
通讯作者：
Chan MD
DOI：
10.1016/j.ijrobp.2007.05.076
发表时间：
2007-12-01
影响因子：
7
作者：
Butler, Jerome M., Jr.;Case, L. Douglas;Shaw, Edward G.
通讯作者：
Shaw, Edward G.
影响因子：
--
作者：
Lopez, OL;Jagust, WJ;Kuller, LH
通讯作者：
Kuller, LH