The interaction of social risk factors and HPA axis dysregulation in predicting emotional symptoms of five- and six-year-old children.
The interaction of social risk factors and HPA axis dysregulation in predicting emotional symptoms of five- and six-year-old children.
复制标题
社会风险因素和 HPA 轴失调在预测五六岁儿童情绪症状中的相互作用。
DOI：
10.1016/j.jpsychires.2011.12.004
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发表时间：
2012
影响因子：
4.8
通讯作者：
M. Hatzinger
中科院分区：
文献类型：
--
作者：
K. von Klitzing;S. Perren;A. Klein;S. Stadelmann;L. White;Maureen Groeben;E. Holsboer;S. Brand;M. Hatzinger
我们研究了社会关系（家庭环境和同伴受害）和神经内分泌（HPA轴失调）的危险因素与儿童情绪症状的联系。我们特别强调这些危险因素的联合影响方面的出现和过程中的情绪symptoms.METHODSOne一百六十六名儿童进行了采访（伯克利木偶采访）在5岁和6岁。教师和家长完成了优势和困难问卷。父母完成了家庭环境量表。同伴受害的教师和儿童的报告进行了评估。在高度结构化的故事完成任务之前和之后，针对他们的认知情绪表征的家庭conflictions.CITTS儿童的唾液皮质醇的测量在横断面分析中，消极的家庭环境，同伴受害，皮质醇增加在故事完成任务独立地有助于情绪症状的方差。家庭环境和皮质醇增加之间存在显著的交互作用：那些经历过不利家庭环境的6岁奥尔兹只有在完成故事任务时皮质醇增加时才会表现出高水平的情绪症状。在纵向分析中，同伴受害在5岁时预测情绪症状的增加，在6岁时，但只为那些孩子表现出迟钝的皮质醇反应一年earlier.CONCLUSIONSSENCE消极的家庭环境和同伴受害被证明是独立相关的情绪症状。HPA轴反应性差异调节这些协会。治疗策略应该考虑到负面关系体验和生物对压力的敏感性之间的相互作用。
OBJECTIVEWe examined the links of social relational (family environment and peer victimization) and neuroendocrinological (HPA axis dysregulation) risk factors to children’s emotional symptoms. We placed special emphasis on the joint effects of these risk factors with respect to the emergence and course of the emotional symptoms.METHODSOne hundred and sixty-six children were interviewed (Berkeley Puppet Interview) at age 5 and 6. Teachers and parents completed the Strengths and Difficulties Questionnaire. Parents completed the Family Environment Scales. Peer victimization was assessed by teacher and child reports. Children’s saliva cortisol was measured before and after a highly structured story completion task which targeted their cognitive emotional representations of family conflicts.RESULTSIn the cross-sectional analyses, negative family environment, peer victimization, and cortisol increase during the story completion task independently contributed to the variance of emotional symptoms. There was a significant interaction effect between family environment and cortisol increase: those six-year-olds who had experienced an unfavorable family environment only showed high levels of emotional symptoms if they exhibited a cortisol increase during the story completion task. In the longitudinal analysis, peer victimization at age 5 predicted an increase of emotional symptoms at age 6, but only for those children who exhibited a blunted cortisol response a year earlier.CONCLUSIONSNegative family environment and peer victimization proved to be independently associated with emotional symptoms. HPA axis reactivity differentially moderated these associations. Therapeutic strategies should take the interaction between negative relational experiences and biological susceptibility to stress into account.
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影响因子：
--
作者：
KESSLER, RC;SONNEGA, A;NELSON, CB
通讯作者：
NELSON, CB
影响因子：
17.7
作者：
Holmans, Peter;Weissman, Myrna M.;Levinson, Douglas F.
通讯作者：
Levinson, Douglas F.
影响因子：
56.9
作者：
KAGAN, J;REZNICK, JS;SNIDMAN, N
通讯作者：
SNIDMAN, N
影响因子：
4.6
作者：
Kochenderfer, BJ;Ladd, GW
通讯作者：
Ladd, GW
儿童和青少年抑郁症：概述：流行病学、临床表现和危险因素。
DOI：
10.1016/j.chc.2006.05.002
发表时间：
2006
影响因子：
2.4
作者：
Zalsman,Gil;Brent,DavidA;Weersing,VRobin
通讯作者：
Weersing,VRobin