Steroid-induced myopathy and its significance to respiratory disease: a known disease rediscovered.
Steroid-induced myopathy and its significance to respiratory disease: a known disease rediscovered.
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类固醇诱发的肌病及其对呼吸系统疾病的意义：重新发现的一种已知疾病。
DOI：
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发表时间：
1992
影响因子：
24.3
通讯作者：
M. Decramer
中科院分区：
文献类型：
--
作者：
P. Dekhuijzen;M. Decramer
骨骼肌肌病是众所周知的系统给药皮质类固醇的副作用。近年来，人们重新关注呼吸肌的受累及其在肺病患者中的意义。已知两种不同的类固醇引起的肌肉变化的临床模式。在短期高剂量类固醇治疗后的急性肌病和萎缩中，包括呼吸肌在内的全身肌肉萎缩和横纹肌溶解发生。慢性类固醇肌病，在长期中等剂量治疗后发生，其特征是逐渐出现近端肢体肌肉无力，并可能伴有呼吸肌力量减少。动物研究表明膈肌病和萎缩与周围骨骼肌的改变相似。氟化类固醇诱导选择性IIb型（快速收缩糖酵解）纤维萎缩，导致横膈膜收缩特性的改变。非氟类固醇也可能引起横膈膜的组织学、生化和功能改变。对胶原血管疾病、哮喘和慢性阻塞性肺疾病（COPD）患者的观察强调了皮质类固醇治疗对呼吸肌结构和功能的潜在危害。
Skeletal muscle myopathy is a well-known side-effect of systemically administered corticosteroids. In recent years renewed attention is being paid to the involvement of the respiratory muscles and its consequent significance in pulmonary patients. Two different clinical patterns of steroid-induced muscular changes are known. In acute myopathy and atrophy after short term treatment with high doses of steroids, generalized muscle atrophy and rhabdomyolysis occur, including the respiratory muscles. Chronic steroid myopathy, occurring after prolonged treatment with moderate doses, is characterized by the gradual onset of proximal limb muscle weakness and may be accompanied by reduced respiratory muscle force. Animal studies demonstrated diaphragmatic myopathy and atrophy similar to the alterations in peripheral skeletal muscles. Fluorinated steroids induced selective type IIb (fast-twitch glycolytic) fibre atrophy, resulting in changes in contractile properties of the diaphragm. Non-fluorinated steroids may also induce histological, biochemical and functional alterations in the diaphragm. Observations in patients with collagen vascular disorders and with asthma and chronic obstructive pulmonary disease (COPD) underline the potential hazards of treatment with corticosteroids to respiratory muscle structure and function.
糖皮质激素引起的萎缩并不是由于大鼠肌肉的兴奋性受损所致。
DOI：
10.1152/ajpendo.1982.243.6.e512
发表时间：
1982
期刊：
The American journal of physiology
影响因子：
--
作者：
Ruff,RL;Martyn,D;Gordon,AM
通讯作者：
Gordon,AM
犬呼吸肌的纤维类型和纤维直径。
DOI：
10.1152/jappl.1987.62.4.1705
发表时间：
1987
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Reid,MB;Ericson,GC;Feldman,HA;JohnsonJr,RL
通讯作者：
JohnsonJr,RL