Protective effects of Morus alba leaves extract on ocular functions of pups from diabetic and hypercholesterolemic mother rats.
Protective effects of Morus alba leaves extract on ocular functions of pups from diabetic and hypercholesterolemic mother rats.
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DOI：
10.7150/ijbs.7.715
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发表时间：
2011
影响因子：
9.2
通讯作者：
Mousa SA
中科院分区：
文献类型：
--
作者：
El-Sayyad HI;El-Sherbiny MA;Sobh MA;Abou-El-Naga AM;Ibrahim MA;Mousa SA
植物疗法通常被认为比合成药物毒性更小，没有副作用。因此，本研究旨在探讨桑叶粗水提取物对糖尿病和/或高胆固醇血症母鼠眼功能的保护作用，包括白内障发生、生化糖尿病和高胆固醇血症标志物、视网膜神经递质和视网膜病变。应用桑树粗水提取物可改善母体血清葡萄糖、低密度脂蛋白、高密度脂蛋白、总胆固醇和肌酸磷酸激酶活性以及视网膜神经递质乙酰胆碱（ACE）、肾上腺素（AD）、非肾上腺素（NAD）、血清素（5-HT）、组胺（HS）、多巴胺（DA）和γ氨基丁酸（GABA）的变化。糖尿病和/或高胆固醇血症母鼠的幼崽视网膜表现出大量的视网膜神经递质改变。视网膜神经递质的改变与观察到的视网膜色素上皮、光感受器内节段和神经节细胞的病理改变以及DNA断裂和细胞凋亡的发生率增加有关。然而，桑树提取物的保护作用导致视网膜神经元和估计的神经递质病理改变的改善。此外，在糖尿病和/或高胆固醇母亲的幼崽中发现了惊人的白内障发生率。联合用药组的白内障发生率最高。我们的数据表明，实验性的母亲糖尿病单独或合并高胆固醇血症会导致其幼鼠的眼部结构改变，白内障和视网膜病变的发病率增加，而提取物的作用可能归因于植物提取物的主要成分黄酮类化合物的降糖、抗高胆固醇和抗氧化潜力。
Phytotherapy is frequently considered to be less toxic and free from side effects than synthetic drugs. Hence, the present study was designed to investigate the protective use of crude water extract of Morus alba leaves on ocular functions including cataractogenesis, biochemical diabetic and hypercholesterolemic markers, retinal neurotransmitters and retinopathy of rat pups maternally subjected to either diabetes and/or hypercholesterolemia. Application of crude water extract of Morus alba resulted in amelioration of the alterations of maternal serum glucose, LDL, HDL, total cholesterol and creatine phosphokinase activity as well as retinal neurotransmitters including acetylcholine (ACE), adrenaline (AD), nor-adrenaline (NAD), serotonin (5-HT), histamine (HS), dopamine (DA) and gamma amino butyric acid (GABA). The retina of pups of either diabetic and/or hypercholesterolemia mothers exhibited massive alterations of retinal neurotransmitters. The alterations of retinal neurotransmitters were correlated with the observed pathological alterations of retinal pigmented epithelium, photoreceptor inner segment and ganglion cells and increased incidence of DNA fragmentation and apoptosis cell death. However, protection with Morus alba extract led to amelioration of the pathological alterations of retinal neurons and estimated neurotransmitters. Furthermore, a striking incidence of cataract was detected in pups of either diabetic and/or hypercholesterolemic mothers. Highest cataractogenesis was observed in pups of combined -treated groups. Our data indicate that experimental maternal diabetes alone or in combination with hypercholesterolemia led to alteration in the ocular structures of their pups, with an increasing incidence of cataract and retinopathy, and the effects of the extract might be attributed to the hypoglycaemic, antihypercholesterolemic and anti-oxidative potential of flavonoids, the major components of the plant extract.
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DOI：
10.1161/01.atv.17.11.2744
发表时间：
1997-11-01
影响因子：
8.7
作者：
Hayek, T;Fuhrman, B;Aviram, M
通讯作者：
Aviram, M
DOI：
10.1002/neu.20200
发表时间：
2006-01-01
期刊：
JOURNAL OF NEUROBIOLOGY
影响因子：
--
作者：
Kraij-Hans, I;Tibber, M;Mobbs, P
通讯作者：
Mobbs, P
影响因子：
2.9
作者：
GILBERSTADT, ML;RUSSELL, JA
通讯作者：
RUSSELL, JA
影响因子：
5.8
作者：
AFANASEV, IB;DOROZHKO, AI;POTAPOVITCH, AI
通讯作者：
POTAPOVITCH, AI
影响因子：
3.4
作者：
Bytyqi, AH;Lockridge, O;Layer, PG
通讯作者：
Layer, PG