Nanoengineered on-demand drug delivery system improves efficacy of pharmacotherapy for epilepsy.
Nanoengineered on-demand drug delivery system improves efficacy of pharmacotherapy for epilepsy.
复制标题
DOI：
10.1126/sciadv.abm3381
复制
发表时间：
2022-01-14
期刊：
影响因子：
13.6
通讯作者：
Wang Y
中科院分区：
文献类型：
--
作者：
Wu D;Fei F;Zhang Q;Wang X;Gong Y;Chen X;Zheng Y;Tan B;Xu C;Xie H;Fang W;Chen Z;Wang Y
电反应和协同脑靶向纳米颗粒提高癫痫药物治疗的疗效。长期药物治疗作为癫痫预防的主要治疗方法，由于血脑屏障（BBB）和用药不及时，其疗效有限，并存在潜在的副作用。在这里，我们报道了一种纳米工程药物递送系统，用于协同脑靶向递送和抗癫痫药物（aed）的按需药物释放。多巴胺-吡咯混合系统可以通过近红外光的光热转换诱导的受体介导的胞质转运和血脑屏障破坏转运的结合来提高递送效率。多多巴胺的掺入使给药系统具有增强的导电性和敏感性，在癫痫样放电反应中给予持续（2小时）和快速（30秒）的药物释放。急性、持续和自发发作模型证实，该输送系统可以抑制癫痫样异常时的发作，治疗剂量为常规剂量的五分之一。与令人满意的生物安全性结果相补充，这种“智能”模式有望成为一种有效和安全的策略，以提高抗癫痫药治疗指数。
Electroresponsive and synergistic brain-targeting nanoparticles improve efficacy of pharmacotherapy for epilepsy. Long-term pharmacotherapy, serving as the main therapeutic approach for epilepsy prophylaxis, has suffered from limited efficacy and potential side effects because of the blood-brain barrier (BBB) and untimely medication. Here, we reported a nanoengineered drug delivery system for synergistic brain-targeting delivery and on-demand drug release of antiepileptic drugs (AEDs). The dopamine-pyrrole hybrid system can improve delivery efficiency through a combination of receptor-mediated transcytosis and BBB disruption–enabled transport induced by photothermal conversion of near-infrared light. Incorporation of polydopamine endowed the delivery system with enhanced conductivity and sensitivity, giving sustained (2 hours) and rapid (30 s) drug release in response to epileptiform discharges. Acute, continuous, and spontaneous seizure models validated that the delivery system could inhibit seizures upon epileptiform abnormalities, treated by one-fifth of the conventional dosage. Complemented with satisfactory biosafety results, this “smart” modality is promising to be an effective and safe strategy to improve the therapeutic index of AEDs for epilepsy.
登录
查看更多内容
使用无毒 AIE 探针对非人灵长类动物进行厘米深 NIR-II 荧光成像
DOI：
10.34133/2020/4074593
发表时间：
2020
期刊：
Research (Washington, D.C.)
影响因子：
--
作者：
Sheng Z;Li Y;Hu D;Min T;Gao D;Ni JS;Zhang P;Wang Y;Liu X;Li K;Zheng H;Tang BZ
通讯作者：
Tang BZ
影响因子：
29.4
作者：
Jiang, Yu;Yang, Weijing;Zhong, Zhiyuan
通讯作者：
Zhong, Zhiyuan
凝血酶响应、脑靶向纳米颗粒可改善中风治疗
影响因子：
17.1
作者：
Guo, Xing;Deng, Gang;Zhou, Jiangbing
通讯作者：
Zhou, Jiangbing
功能化纳米载体结合癫痫特异性载体与 P-糖蛋白调节特性，用于抗癫痫药物输送
影响因子：
14
作者：
Liu, Jiansheng;He, Yajing;Hong, Zhen
通讯作者：
Hong, Zhen
影响因子：
38.1
作者：
Bell, Brian;Lin, Jack J.;Seidenberg, Michael;Hermann, Bruce
通讯作者：
Hermann, Bruce