Peripheral opioid analgesia: from experimental to clinical studies.
Peripheral opioid analgesia: from experimental to clinical studies.
复制标题
外周阿片类镇痛：从实验到临床研究。
DOI：
10.1097/00001503-199910000-00019
复制
发表时间：
1999
期刊：
影响因子：
--
通讯作者：
M. Schäfer
中科院分区：
文献类型：
--
作者：
M. Schäfer
先前的实验结果表明，局部给药阿片类药物产生剂量依赖性和纳洛酮可逆的镇痛作用，这种作用仅限于外周，现已在临床研究中得到证实。因此，在动物和人类的外周感觉神经元上已经发现了阿片受体。外周阿片类药物除了对躯体疼痛有效外，还能有效抑制内脏疼痛。这些作用在炎症条件下增强。目前，初步临床试验已经检查了阿片类药物在慢性炎症状态（如关节炎）中的局部作用。它们表现出令人惊讶的持久镇痛效果，可能是由额外的抗炎作用引起的。引入新一代的阿片类药物，选择性地作用于外周，可能会开辟一种新的方法，有效地治疗疼痛，而不会产生不良的中枢副作用，如呼吸抑制和成瘾。
Previous experimental findings demonstrating that the local administration of opioids produces dose-dependent and naloxone-reversible analgesic effects, which are restricted to the periphery, have now been confirmed in clinical studies. Accordingly, opioid receptors have been identified on peripheral sensory neurons of animals and humans. In addition to their efficacy in somatic pain, peripheral opioids potently inhibit visceral pain. These effects are enhanced under inflammatory conditions. Initial clinical trials have now examined local opioid effects in chronic inflammatory states such as arthritis. They demonstrated surprisingly long-lasting analgesic effects, probably caused by additional anti-inflammatory effects. The introduction of a new generation of opioids that act selectively in the periphery may open a novel approach to treating pain effectively without undesirable central side-effects such as respiratory depression and addiction.
DOI：
10.1172/jci118852
发表时间：
1996-08
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
C. Stein;Martina Pflüger;A. Yassouridis;Jürgen Hoelzl;K. Lehrberger;Carmen Welte;A. Hassan
通讯作者：
C. Stein;Martina Pflüger;A. Yassouridis;Jürgen Hoelzl;K. Lehrberger;Carmen Welte;A. Hassan
影响因子：
2.9
作者：
Krzanowska, EK;Bodnar, RJ
通讯作者：
Bodnar, RJ