Lack of binding between cryoimmunoglobulins, immunoglobulins and fibronectin: implications for immune complex vasculitis
Lack of binding between cryoimmunoglobulins, immunoglobulins and fibronectin: implications for immune complex vasculitis
复制标题
冷冻免疫球蛋白、免疫球蛋白和纤连蛋白之间缺乏结合：对免疫复合物血管炎的影响
DOI：
10.1111/j.1365-2249.1991.tb05588.x
复制
发表时间：
1991
影响因子：
4.6
通讯作者：
V. L. KIMMEL‐TRUITT
中科院分区：
文献类型：
--
作者：
D. Brandau;R. O’Donnell;V. L. KIMMEL‐TRUITT
Immunc‐complex‐mcdiated vasculitis is a frequent complication of rheumatoid arthritis and systemic lupus erythematosus. The mechanism of deposition of immune complexes within the vessel wall in these diseases remains unknown, but probably involves other proteins. Fibronectin is a likely candidate since it possesses the ability to bind to collagen, endothelial cells, and possibly immunoglobulins and immune complexes. In this study, the hinding of libronectin to IgG and IgM cryoglobulins, cold soluble IgM, IgG, IgG subclasses and IgG fragments was investigated in the solution phase. Static light scattering, fluorescence anisotropy. fluorescence intensity, and PEG precipitation studies were used to investigate binding under different conditions of temperature and ionic strength. These studies failed to demonstrate significant binding between fibronectin and IgM, IgG, IgG subclasses and IgG fragments under the conditions studied These findings argue against solution phase binding of fibronectin and immunoglobulins contributing to immune complex vasculitis. The possibility of important surface interactions between these proteins has not been ruled out.
纤连蛋白及其明胶结合域与 I 型胶原荧光标记链的相互作用。
DOI：
--
发表时间：
1988
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Ingham,KC;Brew,SA;Isaacs,BS
通讯作者：
Isaacs,BS
影响因子：
7.5
作者：
MIEKKA, SI;INGHAM, KC;MENACHE, D
通讯作者：
MENACHE, D