Structural parameters of nanoparticles affecting their toxicity for biomedical applications: a review.
Structural parameters of nanoparticles affecting their toxicity for biomedical applications: a review.
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DOI：
10.1007/s11051-023-05690-w
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发表时间：
2023
影响因子：
2.5
通讯作者：
Tayebi, Lobat
中科院分区：
文献类型：
--
作者：
Abbasi, Reza;Shineh, Ghazal;Mobaraki, Mohammadmahdi;Doughty, Sarah;Tayebi, Lobat
人们对将纳米颗粒(NPs)用于生物医学应用的兴趣迅速增长，这增加了人们对其安全性和毒性的担忧。与块状材料相比，纳米粒子具有更大的比表面积和更小的尺寸，因此具有更强的化学活性和毒性。了解NPs的毒性机制，以及影响其在生物环境中行为的因素，可以帮助研究人员设计出副作用更少、性能更好的NPs。本文综述了纳米粒子的分类和性质，讨论了纳米粒子在分子成像和细胞治疗、基因转移、组织工程、靶向给药、抗SARS-CoV-2疫苗、癌症治疗、伤口愈合和抗菌应用等方面的生物医学应用。纳米粒子有不同的毒性机制，其毒性和行为取决于各种因素，本文对此进行了详细的阐述。更具体地说，通过考虑不同的物理化学参数，如大小、形状、结构、团聚状态、表面电荷、润湿性、剂量和物质类型，讨论了毒性机理及其与活性成分的相互作用。聚合物、硅基、碳基和金属基纳米颗粒(包括等离子合金纳米颗粒)的毒性已经被分开考虑。
Rapidly growing interest in using nanoparticles (NPs) for biomedical applications has increased concerns about their safety and toxicity. In comparison with bulk materials, NPs are more chemically active and toxic due to the greater surface area and small size. Understanding the NPs’ mechanism of toxicity, together with the factors influencing their behavior in biological environments, can help researchers to design NPs with reduced side effects and improved performance. After overviewing the classification and properties of NPs, this review article discusses their biomedical applications in molecular imaging and cell therapy, gene transfer, tissue engineering, targeted drug delivery, Anti-SARS-CoV-2 vaccines, cancer treatment, wound healing, and anti-bacterial applications. There are different mechanisms of toxicity of NPs, and their toxicity and behaviors depend on various factors, which are elaborated on in this article. More specifically, the mechanism of toxicity and their interactions with living components are discussed by considering the impact of different physiochemical parameters such as size, shape, structure, agglomeration state, surface charge, wettability, dose, and substance type. The toxicity of polymeric, silica-based, carbon-based, and metallic-based NPs (including plasmonic alloy NPs) have been considered separately.
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影响因子：
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Baldini N