Cytosolic DNA sensing via the stimulator of interferon genes adaptor: Yin and Yang of immune responses to DNA.
Cytosolic DNA sensing via the stimulator of interferon genes adaptor: Yin and Yang of immune responses to DNA.
复制标题
DOI：
10.1002/eji.201344407
复制
发表时间：
2014-10
影响因子：
5.4
通讯作者：
Mellor, Andrew L.
中科院分区：
文献类型：
--
作者：
Lemos, Henrique;Huang, Lei;McGaha, Tracy L.;Mellor, Andrew L.
DNA is immunogenic and many cells express cytosolic DNA sensors that activate the Stimulator of Interferon Genes (STING) adaptor to trigger interferon type I (IFN-β) release, a potent immune activator. DNA sensing to induce IFN-β triggers host immunity to pathogens but constitutive DNA sensing can induce sustained IFN-β release which incites autoimmunity. Here we focus on cytosolic DNA sensing via the STING/IFN-β pathway which regulates immune responses. Recent studies reveal that cytosolic DNA sensing via the STING/IFN-β pathway induces indoleamine 2,3 dioxygenase (IDO), which catabolizes tryptophan to suppress effector and helper T-cell responses and activate Foxp3-lineage CD4+ regulatory T (Treg) cells. During homeostasis, and in some inflammatory settings, specialized innate immune cells in the spleen and lymph nodes may ingest and sense cytosolic DNA to reinforce tolerance that prevents autoimmunity. However, malignancies and pathogens may exploit DNA-induced regulatory responses to suppress natural and vaccine-induced immunity to malignant and infected cells. In this review we discuss the biologic significance of regulatory responses to DNA and novel approaches to exploit DNA-induced responses immune for therapeutic benefit. The ability of DNA to drive tolerogenic or immunogenic responses highlights the need to evaluate immune responses to DNA in physiologic settings relevant to disease progression or therapy.
登录
查看更多内容
影响因子：
5.4
作者：
Bhat N;Fitzgerald KA
通讯作者：
Fitzgerald KA
影响因子：
32.4
作者：
Gall A;Treuting P;Elkon KB;Loo YM;Gale M Jr;Barber GN;Stetson DB
通讯作者：
Stetson DB
影响因子：
16.8
作者：
Munn DH;Mellor AL
通讯作者：
Mellor AL
影响因子：
6.7
作者：
Archer KA;Durack J;Portnoy DA
通讯作者：
Portnoy DA
DOI：
10.4049/jimmunol.1303258
发表时间：
2014-06-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Lemos H;Huang L;Chandler PR;Mohamed E;Souza GR;Li L;Pacholczyk G;Barber GN;Hayakawa Y;Munn DH;Mellor AL
通讯作者：
Mellor AL