Verification of a genetic locus for methamphetamine intake and the impact of morphine.
Verification of a genetic locus for methamphetamine intake and the impact of morphine.
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DOI：
10.1007/s00335-017-9724-5
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发表时间：
2018-04
期刊：
影响因子：
--
通讯作者：
Phillips TJ
中科院分区：
文献类型：
--
作者：
Eastwood EC;Eshleman AJ;Janowsky A;Phillips TJ
A quantitative trait locus (QTL) on proximal chromosome (Chr) 10 accounts for >50% of the genetic variance in methamphetamine (MA) intake in mice selectively bred for high (MAHDR) and low (MALDR) voluntary MA drinking. The μ-opioid receptor (MOP-r) gene, Oprm1, resides at the proximal end of Chr 10, and buprenorphine reduces MA intake in MAHDR mice. However, this drug has only partial agonist effects at MOP-r. We investigated the impact of a full MOP-r agonist, morphine, on MA intake and saccharin intake, measured MOP-r density and affinity in several brain regions of the MA drinking lines and their C57BL/6J (B6) and DBA/2J (D2) progenitor strains, and measured MA intake in two congenic strains of mice to verify the QTL and reduce the QTL interval. Morphine reduced MA intake in the MAHDR line, but also reduced saccharin and total fluid intake. MOP-r density was lower in the medial prefrontal cortex of MAHDR, compared to MALDR, mice, but not in the nucleus accumbens or ventral midbrain; there were no MOP-r affinity differences. No significant differences in MOP-r density or affinity were found between the progenitor strains. Finally, Chr 10 congenic results were consistent with previous data suggesting that Oprm1 is not a quantitative trait gene, but is impacted by the gene network underlying MA intake. Stimulation of opioid pathways by a full agonist can reduce MA intake, but may also non-specifically affect consummatory behavior; thus, a partial agonist may be a better pharmacotherapeutic.
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DOI：
10.1111/j.1530-0277.2006.00215.x
发表时间：
2006-10-01
影响因子：
3.2
作者：
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通讯作者：
Ozaki, Norio
影响因子：
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作者：
Gubner, Noah R.;Reed, Cheryl;McKinnon, Carrie S.;Phillips, Tamara J.
通讯作者：
Phillips, Tamara J.
DOI：
10.1124/jpet.107.119560
发表时间：
2007-10-01
影响因子：
3.5
作者：
Kalvass, J. Cory;Olson, Emily R.;Pollack, Gary M.
通讯作者：
Pollack, Gary M.
影响因子：
3.4
作者：
Eastwood EC;Phillips TJ
通讯作者：
Phillips TJ
DOI：
10.1111/gbb.12100
发表时间：
2014-02
期刊：
Genes, brain, and behavior
影响因子：
--
作者：
Eastwood EC;Phillips TJ
通讯作者：
Phillips TJ