Unique genetic factors influence sensitivity to the rewarding and aversive effects of methamphetamine versus cocaine.
Unique genetic factors influence sensitivity to the rewarding and aversive effects of methamphetamine versus cocaine.
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DOI：
10.1016/j.bbr.2013.08.035
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发表时间：
2013-11-01
影响因子：
2.7
通讯作者：
Phillips, Tamara J.
中科院分区：
文献类型：
--
作者：
Gubner, Noah R.;Reed, Cheryl;McKinnon, Carrie S.;Phillips, Tamara J.
关键词：
遗传因素显着影响成瘾相关的表型。这得到了两组重复小鼠品系的甲基苯丙胺消耗量的成功双向选择性育种的支持。以前已经发现，影响甲基苯丙胺消费的一些相同的遗传因素也会影响对甲基苯丙胺的条件奖励和厌恶效应的敏感性。目前研究的目的是确定是否有一些相同的遗传因素影响对可卡因的条件奖励和厌恶效应的敏感性。使用条件性位置偏好程序在甲基苯丙胺高饮酒和低饮酒线小鼠中检查可卡因条件性奖赏，并且使用条件性味觉厌恶程序测量可卡因条件性厌恶。此外，一般的敏感性措施，可卡因的运动刺激反应，在这些线路进行了评估;以前的数据表明，所选线路之间的甲基苯丙胺诱导的刺激的敏感性没有差异。与甲基苯丙胺的显著差异相反，甲基苯丙胺高和低饮酒线对可卡因的奖励或厌恶效应的敏感性没有差异。它们对可卡因诱导的运动刺激也表现出相当的敏感性。这些数据表明，遗传因素的影响敏感性的条件奖励和厌恶的影响甲基苯丙胺在这些线的小鼠不影响敏感性可卡因的这些影响。因此，不同的遗传因素可能会影响甲基苯丙胺与可卡因使用的风险。
Genetic factors significantly influence addiction-related phenotypes. This is supported by the successful bidirectional selective breeding of two replicate sets of mouse lines for amount of methamphetamine consumed. Some of the same genetic factors that influence methamphetamine consumption have been previously found also to influence sensitivity to the conditioned rewarding and aversive effects of methamphetamine. The goal of the current studies was to determine if some of the same genetic factors influence sensitivity to the conditioned rewarding and aversive effects of cocaine. Cocaine conditioned reward was examined in methamphetamine high drinking and low drinking line mice using a conditioned place preference procedure and cocaine conditioned aversion was measured using a conditioned taste aversion procedure. In addition, a general sensitivity measure, locomotor stimulant response to cocaine, was assessed in these lines; previous data indicated no difference between the selected lines in sensitivity to methamphetamine-induced stimulation. In contrast to robust differences for methamphetamine, the methamphetamine high and low drinking lines did not differ in sensitivity to either the rewarding or aversive effects of cocaine. They also exhibited comparable sensitivity to cocaine-induced locomotor stimulation. These data suggest that the genetic factors that influence sensitivity to the conditioned rewarding and aversive effects of methamphetamine in these lines of mice do not influence sensitivity to these effects of cocaine. Thus, different genetic factors may influence risk for methamphetamine versus cocaine use.
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DOI：
10.1186/1471-2210-6-6
发表时间：
2006-03-03
期刊：
BMC pharmacology
影响因子：
--
作者：
Han DD;Gu HH
通讯作者：
Gu HH
影响因子：
10.5
作者：
Kendler, KS;Prescott, CA
通讯作者：
Prescott, CA
影响因子：
3.4
作者：
Cunningham, CL;Dickinson, SD;McMullin, CS
通讯作者：
McMullin, CS
影响因子：
3.6
作者：
Newton, TF;De La Garza, R;Nestor, L
通讯作者：
Nestor, L
影响因子：
1.9
作者：
Grigson, PS;Twining, RC
通讯作者：
Twining, RC