Glycolytic and lipid oxidative metabolic programs are essential for freshly-isolated regulatory T cells in mice with sepsis.
Glycolytic and lipid oxidative metabolic programs are essential for freshly-isolated regulatory T cells in mice with sepsis.
复制标题
糖酵解和脂质氧化代谢程序对于脓毒症小鼠中新鲜分离的调节性 T 细胞至关重要。
作者：
免疫代谢决定调节性T细胞的命运和功能。调节性T细胞（regulatory T cells, Treg）的代谢表型受多种因素影响。Treg代谢与脓毒症小鼠功能的关系尚不清楚。我们采用液相色谱和串联质谱（LC-MS/MS）分析了脓毒症小鼠新鲜分离脾脏Treg细胞的代谢谱。研究发现，在严重感染时，活化的Treg细胞依赖于糖酵解和脂肪酸氧化，代谢途径的抑制对Treg细胞的数量和质量有显著影响。了解Treg细胞在体内真实环境中的代谢特性，有助于掌握Treg细胞的功能，甚至整体免疫状态。靶向Treg代谢途径可能为脓毒症的治疗提供一种新的方法。新分离的Treg细胞在脓毒症小鼠中表现出代谢重编程，主要表现为糖酵解和脂肪酸氧化途径增加。
Immunometabolism determines the fate and function of regulatory T cells. The metabolic phenotype of regulatory T cells (Treg) is affected by various factors. The relationship between Treg metabolism and function of mice with sepsis is not clear. We used liquid chromatography and tandem mass spectrometry (LC-MS/MS) to analyze the metabolic profiles of freshly-isolated spleen Treg cells in mice with sepsis. It was found that in severe infection, activated Treg cells depend on glycolysis and fatty acid oxidation, and inhibition of metabolic pathways has a significant impact on the number and quality of Treg cells. Understanding the metabolic characteristics of Treg cells in the real environment in the body helps to grasp the function of Treg cells and even the overall immune status. Targeting the metabolic pathway of Treg may provide a new method for the treatment of sepsis. Freshly-isolated Treg cells showed metabolic reprogramming in mice with sepsis, mainly manifested by increased glycolysis and fatty acid oxidation pathways.
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影响因子：
120.7
作者：
Boomer, Jonathan S.;To, Kathleen;Chang, Kathy C.;Takasu, Osamu;Osborne, Dale F.;Walton, Andrew H.;Bricker, Traci L.;Jarman, Stephen D., II;Kreisel, Daniel;Krupnick, Alexander S.;Srivastava, Anil;Swanson, Paul E.;Green, Jonathan M.;Hotchkiss, Richard S.
通讯作者：
Hotchkiss, Richard S.
DOI：
10.1038/nri3552
发表时间：
2013-12
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
影响因子：
4.4
作者：
Scumpia, Philip O.;Delano, Matthew J.;Moldawer, Lyle L.
通讯作者：
Moldawer, Lyle L.
影响因子：
64.5
作者：
Ho PC;Bihuniak JD;Macintyre AN;Staron M;Liu X;Amezquita R;Tsui YC;Cui G;Micevic G;Perales JC;Kleinstein SH;Abel ED;Insogna KL;Feske S;Locasale JW;Bosenberg MW;Rathmell JC;Kaech SM
通讯作者：
Kaech SM
影响因子：
29
作者：
Macintyre AN;Gerriets VA;Nichols AG;Michalek RD;Rudolph MC;Deoliveira D;Anderson SM;Abel ED;Chen BJ;Hale LP;Rathmell JC
通讯作者：
Rathmell JC