PlrA (MSMEG_5223) is an essential polar growth regulator in Mycobacterium smegmatis.

PlrA (MSMEG_5223) is an essential polar growth regulator in Mycobacterium smegmatis.
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DOI:
10.1371/journal.pone.0280336
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发表时间:
2023
期刊:
影响因子:
3.7
通讯作者:
Boutte, Cara
Boutte, Cara
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Quintanilla, Samantha C.;Arejan, Neda Habibi;Patel, Parthvi;Boutte, Cara

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分枝杆菌在细胞两极以一种在分子水平上没有很好描述的方式扩展它们的细胞壁。在这项研究中,我们确定了一个新的极性因子,PlrA,这是参与限制肽聚糖代谢的细胞极在耻垢分枝杆菌。我们确定,只有N-末端膜结构域的PlrA是必不可少的。我们发现plrA表型拷贝的消耗耗尽极性生长因子Wag 31,并且PlrA参与调节Wag 31极性灶。
Mycobacteria expand their cell walls at the cell poles in a manner that is not well described at the molecular level. In this study, we identify a new polar factor, PlrA, that is involved in restricting peptidoglycan metabolism to the cell poles in Mycobacterium smegmatis. We establish that only the N-terminal membrane domain of PlrA is essential. We show that depletion of plrA pheno-copies depletion of polar growth factor Wag31, and that PlrA is involved in regulating the Wag31 polar foci.
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