Facile preparation of hybrid vesicles loaded with silica nanoparticles via aqueous photoinitiated polymerization-induced self-assembly

Facile preparation of hybrid vesicles loaded with silica nanoparticles via aqueous photoinitiated polymerization-induced self-assembly
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通过水性光引发聚合诱导的自组装轻松制备负载二氧化硅纳米粒子的杂化囊泡

DOI:
10.1039/c7ra02770b
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发表时间:
2017-04
期刊:
影响因子:
3.9
通讯作者:
Zhang Li
Zhang Li
中科院分区:
化学3区
文献类型:
--
作者:
Tan Jianbo;Liu Dongdong;Zhang Xuechao;Huang Chundong;He Jun;Xu Qin;Li Xueliang;Zhang Li

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我们报告了一个室温光引发聚合诱导自组装(光PISA)的2-羟丙基甲基丙烯酸酯(HPMA)在二氧化硅纳米粒子的存在下,使用聚(乙二醇)甲基醚(mPEG)大分子链转移剂(macro-CTA)。通过这种一锅法获得了负载有二氧化硅纳米颗粒的杂化囊泡。聚合物囊泡的固体含量可高达25%w/w。进行对照实验以证明游离的二氧化硅纳米颗粒可以通过离心-再分散除去。最后,利用HPMA和甲基丙烯酸二甲氨基乙酯(DMAEMA)的光致PISA法制备了CO2响应性杂化囊泡。随后在室温下通过CO2鼓泡从囊泡中释放二氧化硅纳米颗粒。
We report a room-temperature photoinitiated polymerization-induced self-assembly (photo-PISA) of 2-hydroxypropyl methacrylate (HPMA) in the presence of silica nanoparticles using a poly(ethylene glycol) methyl ether (mPEG) macromolecular chain transfer agent (macro-CTA). Hybrid vesicles loaded with silica nanoparticles were obtained by this one-pot approach. The solids content of the polymer vesicles can be up to 25% w/w. A control experiment was conducted to prove that free silica nanoparticles can be removed via centrifugation-redispersion. Finally, CO2-responsive hybrid vesicles were prepared by photo-PISA of HPMA and 2-(dimethylamino)ethyl methacrylate (DMAEMA). Silica nanoparticles were subsequently released from the vesicles via CO2 bubbling at room temperature.
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