Gender and age interact to affect early outcome after intracerebral hemorrhage.
Gender and age interact to affect early outcome after intracerebral hemorrhage.
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DOI：
10.1371/journal.pone.0081664
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
James ML
中科院分区：
文献类型：
--
作者：
Umeano O;Phillips-Bute B;Hailey CE;Sun W;Gray MC;Roulhac-Wilson B;McDonagh DL;Kranz PG;Laskowitz DT;James ML
脑出血（ICH）是一种常见的、毁灭性的脑血管疾病。在脑出血中，对结果的性别差异的研究相对较少，但在其他神经急症中已进行了检查。此外，年龄和性别对脑出血后预后的潜在影响尚未探讨。本研究旨在验证年龄和性别相互作用改变脑出血后神经预后的假设。通过对杜克大学现有卒中数据库的回顾性分析，对2007年7月至2010年4月收治的自发性原发性幕上脑出血成年患者进行了评估。对收集的变量进行单因素分析，比较性别和结果。不良结果定义为出院或死亡。采用多元回归分析年龄和性别对脑出血后转归的综合影响。在该研究人群中，与男性相比，女性更年轻（61.1+14.5岁对65.8+17.3岁，p=0.03），更有可能有药物滥用史（35%对8.9%,p<0.0001）。多变量模型表明，与男性相比，年龄增长对女性出院结果的预测作用更大（p=0.02）。对于年轻患者，女性具有保护作用；然而，在60岁以上的人群中，女性性别是出院或死亡的风险因素。在单中心队列中，性别和年龄的交互作用效应与脑出血后早期预后的相关性显著增强，而与脑出血后临终关怀出院或死亡独立相关。需要前瞻性研究来验证这些发现。
Intracerebral hemorrhage (ICH) is a common and devastating form of cerebrovascular disease. In ICH, gender differences in outcomes remain relatively understudied but have been examined in other neurological emergencies. Further, a potential effect of age and gender on outcomes after ICH has not been explored. This study was designed to test the hypothesis that age and gender interact to modify neurological outcomes after ICH. Adult patients admitted with spontaneous primary supratentorial ICH from July 2007 through April 2010 were assessed via retrospective analysis of an existing stroke database at Duke University. Univariate analysis of collected variables was used to compare gender and outcome. Unfavorable outcome was defined as discharge to hospice or death. Using multivariate regression, the combined effect of age and gender on outcome after ICH was analyzed. In this study population, women were younger (61.1+14.5 versus 65.8+17.3 years, p=0.03) and more likely to have a history of substance abuse (35% versus 8.9%, p<0.0001) compared to men. Multivariable models demonstrated that advancing age had a greater effect on predicting discharge outcome in women compared to men (p=0.02). For younger patients, female sex was protective; however, at ages greater than 60 years, female sex was a risk factor for discharge to hospice or death. While independently associated with discharge to hospice or death after ICH, the interaction effect between gender and age demonstrated significantly stronger correlation with early outcome after ICH in a single center cohort. Prospective study is required to verify these findings.
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影响因子：
6.9
作者：
Lei, Beilei;Mace, Brian;Bellows, Steven T.;Sullivan, Patrick M.;Vitek, Michael P.;Laskowitz, Daniel T.;James, Michael L.
通讯作者：
James, Michael L.
影响因子：
8.3
作者：
Hemphill, JC;Bonovich, DC;Johnston, SC
通讯作者：
Johnston, SC
DOI：
10.1159/000346599
发表时间：
2013
期刊：
Cerebrovascular diseases (Basel, Switzerland)
影响因子：
--
作者：
Brouwers HB;Greenberg SM
通讯作者：
Greenberg SM
影响因子：
158.5
作者：
Mayer, Stephan A.;Brun, Nikolai C.;Steiner, Thorsten
通讯作者：
Steiner, Thorsten
DOI：
10.1007/978-3-7091-0693-8_18
发表时间：
2011-01-01
期刊：
INTRACEREBRAL HEMORRHAGE RESEARCH: FROM BENCH TO BEDSIDE
影响因子：
--
作者：
Gong, Ye;He, Yangdong;Hua, Ya
通讯作者：
Hua, Ya