Renal recruitment of B lymphocytes exacerbates tubulointerstitial fibrosis by promoting monocyte mobilization and infiltration after unilateral ureteral obstruction.
Renal recruitment of B lymphocytes exacerbates tubulointerstitial fibrosis by promoting monocyte mobilization and infiltration after unilateral ureteral obstruction.
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单侧输尿管梗阻后，B 淋巴细胞的肾脏募集通过促进单核细胞动员和浸润而加剧肾小管间质纤维化。
DOI：
10.1002/path.4831
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发表时间：
2017-01
期刊：
影响因子：
--
通讯作者：
Zhang R
中科院分区：
文献类型：
--
作者：
Han H;Zhu J;Wang Y;Zhu Z;Chen Y;Lu L;Jin W;Yan X;Zhang R
肾纤维化是全球公共卫生的重大威胁。不同的主要病因最终导致慢性肾脏病（CKD），免疫细胞影响这一过程。单核细胞/巨噬细胞、T细胞和肥大细胞的作用已被仔细检查，而只有少数研究集中在B细胞的作用上。我们使用遗传性B细胞缺陷的μMT小鼠或CD 20抗体介导的B细胞缺失小鼠，研究了单侧输尿管梗阻（UUO）诱导的肾小管间质纤维化中的B细胞功能。与野生型小鼠相比，μMT和抗CD 20处理小鼠的阻塞肾脏显示出较低水平的单核细胞/巨噬细胞浸润和胶原沉积。从机制上讲，抗CD 20减弱了UUO诱导的肾脏肿瘤坏死因子-α（TNF-α）、血管细胞粘附分子1（VCAM-1）促炎基因和CC趋化因子配体-2（CCL 2）的改变，这些基因对单核细胞募集至关重要; B细胞是UUO后肾脏中CCL 2的主要来源之一。CCL 2的中和减少了阻塞肾脏中单核细胞/巨噬细胞的流入和纤维化变化。因此，B细胞在肾脏中的早期蓄积加速了单核细胞/巨噬细胞的动员和浸润，加重了急性诱导的肾病引起的纤维化。© 2016作者。病理学杂志由John Wiley & Sons Ltd代表大不列颠和爱尔兰病理学会出版。
Renal fibrosis is a significant threat to public health globally. Diverse primary aetiologies eventually result in chronic kidney disease (CKD) and immune cells influence this process. The roles of monocytes/macrophages, T cells, and mast cells have been carefully examined, whilst only a few studies have focused on the effect of B cells. We investigated B‐cell function in tubulointerstitial fibrosis induced by unilateral ureteral obstruction (UUO), using genetic B‐cell‐deficient μMT mice or CD20 antibody‐mediated B‐cell‐depleted mice. Obstructed kidneys of μMT and anti‐CD20‐treated mice showed lower levels of monocyte/macrophage infiltration and collagen deposition compared to wild‐type mice. Mechanistically, anti‐CD20 attenuated UUO‐induced alterations of renal tumour necrosis factor‐α (TNF‐α), vascular cell adhesion molecule 1 (VCAM‐1) pro‐inflammatory genes, and CC chemokine ligand‐2 (CCL2) essential for monocyte recruitment; B cells were one of the main sources of CCL2 in post‐UUO kidneys. Neutralization of CCL2 reduced monocyte/macrophage influx and fibrotic changes in obstructed kidneys. Therefore, early‐stage accumulation of B cells in the kidney accelerated monocyte/macrophage mobilization and infiltration, aggravating the fibrosis resulting from acutely induced kidney nephropathy. © 2016 The Authors. Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.
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DOI：
10.1016/j.bbrc.2013.07.025
发表时间：
2013-08-23
影响因子：
3.1
作者：
Gonzalez, Julien;Mouttalib, Sofia;Delage, Christine;Calise, Denis;Maoret, Jean-Jose;Pradere, Jean-Philippe;Klein, Julie;Buffin-Meyer, Benedicte;Van der Veen, Betty;Charo, Israel F.;Heeringa, Peter;Duchene, Johan;Bascands, Jean-Loup;Schanstra, Joost-Peter
通讯作者：
Schanstra, Joost-Peter
DOI：
10.1084/jem.20101715
发表时间：
2011-08-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Kelly-Scumpia KM;Scumpia PO;Weinstein JS;Delano MJ;Cuenca AG;Nacionales DC;Wynn JL;Lee PY;Kumagai Y;Efron PA;Akira S;Wasserfall C;Atkinson MA;Moldawer LL
通讯作者：
Moldawer LL
影响因子：
7.3
作者：
Vinuesa, E.;Hotter, G.;Sola, A.
通讯作者：
Sola, A.
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
120.7
作者：
Coresh, Josef;Selvin, Elizabeth;Levey, Andrew S.
通讯作者：
Levey, Andrew S.