Two-week dietary soy supplementation has an estrogenic effect on normal premenopausal breast.
Two-week dietary soy supplementation has an estrogenic effect on normal premenopausal breast.
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两周膳食大豆补充剂对正常绝经前乳房具有雌激素作用。
DOI：
10.1210/jcem.84.11.6152
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
N. Bundred
中科院分区：
文献类型：
--
作者：
D. Hargreaves;C. Potten;C. Harding;L. E. Shaw;M. Morton;S. Roberts;A. Howell;N. Bundred
据报道，在东南亚人群中，高大豆饮食的消费与乳腺癌的低发病率之间存在关联。大豆中存在的植物雌激素作为部分雌激素激动剂或拮抗剂，在体外可以抑制乳腺癌细胞的增殖。测定了84名绝经前患者在饮食中补充60 g（45 mg大豆酮）大豆14天对正常乳腺的影响。补充大豆后，患者血清中异黄酮、染料木黄酮、大豆黄酮和雌马酚的浓度升高（P <或= 0.025）。乳头吸出物（NA）中染料木黄酮和大豆苷元的水平高于配对血清水平，在补充大豆之前（分别为P < 0.001和P = 0.001）和之后（分别为P < 0.001和P = 0.049）;然而，大豆对NA β水平的反应没有显著增加。补充大豆后，载脂蛋白D的NA水平显著降低，而pS2水平升高（P <或= 0.002），表明存在雌激素刺激。大豆补充对乳腺上皮细胞增殖、雌激素和孕激素受体状态、细胞凋亡、有丝分裂或Bcl-2表达没有影响。总之，通过乳头抽吸物载脂蛋白D和pS2表达测定，短期饮食大豆对乳房具有弱雌激素反应。没有检测到大豆对乳房的抗雌激素作用。
An association has been reported between consumption of a high soy diet and a low incidence of breast cancer within populations of Southeast Asia. Phytoestrogens present in soy act as partial estrogen agonists or antagonists and can inhibit breast cancer cell proliferation in vitro. The effect of 14-day dietary soy supplementation with 60 g (45 mg isoflavones) on the normal breast of 84 premenopausal patients was determined. Serum concentrations of the isoflavanoids, genistein, daidzein, and equol, were raised in patients after soy supplementation (P < or = 0.025). Nipple aspirate (NA) levels of genistein and daidzein were higher than paired serum levels, both before (P < 0.001 and P = 0.001, respectively) and after soy supplementation (P < 0.001 and P = 0.049, respectively); however, there was no significant increase in NA isoflavone levels in response to soy. NA levels of apolipoprotein D were significantly lowered and pS2 levels raised in response to soy supplementation (P < or = 0.002), indicative of an estrogenic stimulus. No effect of soy supplementation on breast epithelial cell proliferation, estrogen and progesterone receptor status, apoptosis, mitosis, or Bcl-2 expression was detected. In conclusion, short term dietary soy has a weak estrogenic response on the breast, as measured by nipple aspirate apolipoprotein D and pS2 expression. No antiestrogenic effect of soy on the breast was detected.
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植物雌激素：流行病学和在癌症保护中的可能作用。
影响因子：
10.4
作者：
通讯作者：
--
影响因子：
4.2
作者：
XU, X;HARRIS, KS;HENDRICH, S
通讯作者：
HENDRICH, S
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DOI：
--
发表时间：
1996
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
影响因子：
--
作者：
Petrakis,NL;Barnes,S;King,EB;Lowenstein,J;Wiencke,J;Lee,MM;Miike,R;Kirk,M;Coward,L
通讯作者：
Coward,L
影响因子：
11.2
作者：
R. Severson;A. Nomura;J. Grove;G. Stemmermann
通讯作者：
R. Severson;A. Nomura;J. Grove;G. Stemmermann
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影响因子：
2
作者：
Rajah,TT;Dunn,ST;Pento,JT
通讯作者：
Pento,JT