Effects of α‐adrenoceptor agonists and antagonists on ouabain‐induced arrhythmias and cardiac arrest in guinea‐pig
Effects of α‐adrenoceptor agonists and antagonists on ouabain‐induced arrhythmias and cardiac arrest in guinea‐pig
复制标题
α-肾上腺素受体激动剂和拮抗剂对哇巴因诱导的豚鼠心律失常和心脏骤停的影响
DOI：
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发表时间：
1986
影响因子：
7.3
通讯作者：
Rajit M. Tripathi
中科院分区：
文献类型：
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作者：
G. Thomas;Rajit M. Tripathi
1研究了α1和α2受体不同亲和力的α受体激动剂和拮抗剂对哇巴因诱发豚鼠心律失常的影响。2通过缓慢静脉输注哇巴因在麻醉豚鼠中诱导早期心律失常、室颤和心脏骤停。3苯乙哌啶和育亨宾可明显增强哇巴因的心脏毒性，哌唑嗪和可乐定则有明显的抗心肌缺血作用，并能延缓心脏停搏。4可以得出结论，选择性α1受体刺激和α2受体阻滞剂增加哇巴因的心脏毒性作用，选择性α2受体刺激和α1受体阻滞剂抑制哇巴因诱导的豚鼠心律失常和心脏骤停。
1 Effects of α‐adrenoceptor agonists and antagonists with different affinity for α1‐ and α2‐receptors on ouabain‐induced arrhythmias in guinea‐pigs were studied. 2 Early arrhythmias, ventricular fibrillation and cardiac arrest were induced in anaesthetized guinea‐pigs by the slow intravenous infusion of ouabain. 3 Phenylephrine and yohimbine potentiated the cardiotoxicity of ouabain significantly whereas prazosin and clonidine showed significant antiarrhythmic effects and delayed the cardiac arrest. 4 It is concluded that selective α1‐receptor stimulation and α2‐receptor blockade increases the cardiotoxic effects of ouabain and selective α2‐receptor stimulation and α1‐receptor blockade inhibits ouabain‐induced arrhythmias and cardiac arrest in guinea‐pigs.
豚鼠离体灌注心脏冠状动脉血流改变引起的洋地黄引起的心律失常的耐受性降低。
影响因子：
6.1
作者：
Kim,DH;Akera,T;Kennedy,RH;Stemmer,PM
通讯作者：
Stemmer,PM