Externalizing psychopathology and gain-loss feedback in a simulated gambling task: dissociable components of brain response revealed by time-frequency analysis.
Externalizing psychopathology and gain-loss feedback in a simulated gambling task: dissociable components of brain response revealed by time-frequency analysis.
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DOI：
10.1037/a0022124
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发表时间：
2011-05
影响因子：
4.6
通讯作者：
Patrick, Christopher J.
中科院分区：
文献类型：
--
作者：
Bernat, Edward M.;Nelson, Lindsay D.;Steele, Vaughn R.;Gehring, William J.;Patrick, Christopher J.
外化是一个广泛的概念，反映了对各种冲动控制问题的倾向，包括反社会人格障碍和物质使用障碍。两个事件相关的潜在反应，已知会减少在个人高的外化倾向是P300，这反映了知觉后处理的刺激，和错误相关的负性（ERN），指标性能监测的基础上内源性的代表。目前的研究采用了模拟赌博任务，以检查外化倾向和反馈相关的负性（FRN），一个大脑反应，指标性能监测有关的外源性线索，这被认为是高度相关的ERN之间的关系。时频（TF）分析被用来解开FRN从伴随的P300反应的反馈线索，通过解析的整体反馈锁定电位为独特的theta（4-7 Hz）和delta（< 3 Hz）TF组件。而三角洲P300振幅降低高的个人外化倾向，θ-FRN反应无关外化。这些研究结果表明，与以前报道的赤字在内源性为基础的性能监测（索引的ERN），高外化倾向的个人表现出完整的监测外源性线索（索引的FRN）。这些结果也有助于越来越多的证据表明，P300是在广泛的任务条件下，在高外化的个人衰减。
Externalizing is a broad construct that reflects propensity toward a variety of impulse control problems, including antisocial personality disorder and substance use disorders. Two event-related potential responses known to be reduced among individuals high in externalizing proneness are the P300, which reflects post-perceptual processing of a stimulus, and the error-related negativity (ERN), which indexes performance monitoring based on endogenous representations. The current study employed a simulated gambling task to examine the relationship between externalizing proneness and the feedback-related negativity (FRN), a brain response that indexes performance monitoring related to exogenous cues, which is thought to be highly related to the ERN. Time-frequency (TF) analysis was used to disentangle the FRN from the accompanying P300 response to feedback cues by parsing the overall feedback-locked potential into distinctive theta (4–7 Hz) and delta (< 3 Hz) TF components. Whereas delta-P300 amplitude was reduced among individuals high in externalizing proneness, theta-FRN response was unrelated to externalizing. These findings suggest that, in contrast with previously reported deficits in endogenously-based performance monitoring (as indexed by the ERN), individuals high in externalizing tendencies show intact monitoring of exogenous cues (as indexed by the FRN). The results also contribute to a growing body of evidence indicating that the P300 is attenuated across a broad range of task conditions in high-externalizing individuals.
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影响因子：
56.9
作者：
Gehring, WJ;Willoughby, AR
通讯作者：
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3
作者：
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作者：
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作者：
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作者：
Frank, MJ;Woroch, BS;Curran, T
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