Cancer and Thrombosis: The Platelet Perspective.
Cancer and Thrombosis: The Platelet Perspective.
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DOI：
10.3389/fcell.2016.00147
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发表时间：
2016
影响因子：
5.5
通讯作者：
Worth RG
中科院分区：
文献类型：
--
作者：
Meikle CK;Kelly CA;Garg P;Wuescher LM;Ali RA;Worth RG
血小板对止血和免疫功能至关重要，是癌症进展、转移和癌症相关血栓形成的关键因素。血小板与免疫细胞相互作用以刺激抗肿瘤反应，并且可以被免疫细胞和肿瘤细胞激活。血小板活化可导致血小板与肿瘤细胞之间的复杂相互作用。血小板通过以下方式促进癌症进展和转移：（1）与肿瘤细胞形成聚集体;（2）诱导肿瘤生长、上皮-间充质转化和侵袭;（3）保护循环肿瘤细胞免受免疫监视和杀伤;（4）促进循环肿瘤细胞的束缚和停滞;以及（5）促进血管生成和肿瘤细胞在远端部位的建立。肿瘤细胞活化的血小板也使癌症患者易于发生血栓形成事件。肿瘤细胞和肿瘤衍生的微粒通过分泌促凝血因子导致血栓形成，从而导致血小板活化和凝血。血小板在癌症进展和血栓形成中起关键作用，并且血小板-肿瘤细胞相互作用的标志物是癌症进展和血栓形成风险的生物标志物的候选者。
Platelets are critical to hemostatic and immunological function, and are key players in cancer progression, metastasis, and cancer-related thrombosis. Platelets interact with immune cells to stimulate anti-tumor responses and can be activated by immune cells and tumor cells. Platelet activation can lead to complex interactions between platelets and tumor cells. Platelets facilitate cancer progression and metastasis by: (1) forming aggregates with tumor cells; (2) inducing tumor growth, epithelial-mesenchymal transition, and invasion; (3) shielding circulating tumor cells from immune surveillance and killing; (4) facilitating tethering and arrest of circulating tumor cells; and (5) promoting angiogenesis and tumor cell establishment at distant sites. Tumor cell-activated platelets also predispose cancer patients to thrombotic events. Tumor cells and tumor-derived microparticles lead to thrombosis by secreting procoagulant factors, resulting in platelet activation and clotting. Platelets play a critical role in cancer progression and thrombosis, and markers of platelet-tumor cell interaction are candidates as biomarkers for cancer progression and thrombosis risk.
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影响因子：
--
作者：
Bendas G;Borsig L
通讯作者：
Borsig L
影响因子：
6
作者：
Berlacher, Mark D.;Vieth, Joshua A.;Worth, Randall G.
通讯作者：
Worth, Randall G.
影响因子：
6.5
作者：
BOUKERCHE, H;BERTHIERVERGNES, O;MCGREGOR, JL
通讯作者：
MCGREGOR, JL
影响因子：
3.1
作者：
Chadha, Awalpreet S.;Kocak-Uzel, Esengul;Krishnan, Sunil
通讯作者：
Krishnan, Sunil
影响因子：
4.3
作者：
Antczak, Adam J.;Singh, Navinderjit;Worth, Randall G.
通讯作者：
Worth, Randall G.