The Lymphatic System in Zebrafish Heart Development, Regeneration and Disease Modeling.

The Lymphatic System in Zebrafish Heart Development, Regeneration and Disease Modeling.
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DOI:
10.3390/jcdd8020021
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发表时间:
2021-02-19
影响因子:
2.4
通讯作者:
Harrison MRM
Harrison MRM
中科院分区:
医学3区
文献类型:
--
作者:
Feng X;Travisano S;Pearson CA;Lien CL;Harrison MRM

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Heart disease remains the single largest cause of death in developed countries, and novel therapeutic interventions are desperately needed to alleviate this growing burden. The cardiac lymphatic system is the long-overlooked counterpart of the coronary blood vasculature, but its important roles in homeostasis and disease are becoming increasingly apparent. Recently, the cardiac lymphatic vasculature in zebrafish has been described and its role in supporting the potent regenerative response of zebrafish heart tissue investigated. In this review, we discuss these findings in the wider context of lymphatic development, evolution and the promise of this system to open new therapeutic avenues to treat myocardial infarction and other cardiopathologies.
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