Cough receptor sensitivity and bronchial responsiveness in normal and asthmatic subjects.
Cough receptor sensitivity and bronchial responsiveness in normal and asthmatic subjects.
复制标题
正常和哮喘受试者的咳嗽受体敏感性和支气管反应性。
DOI：
--
复制
发表时间：
1992
影响因子：
24.3
通讯作者：
T. Matsuda
中科院分区：
文献类型：
--
作者：
M. Fujimura;S. Sakamoto;Y. Kamio;T. Matsuda
我们研究了气道咳嗽受体敏感性是否与非特异性支气管反应性相关。我们测量了38名正常人和11名哮喘受试者的咳嗽阈值，吸入酒石酸引起5次或更多次咳嗽的最低浓度，以及乙酰甲胆碱在一秒钟内产生20%的用力呼气量下降（PC 20 FEV 1）的激发浓度。所有受试者均为非吸烟者。正常人和哮喘患者的PC 20 FEV 1几何平均值分别为25.7mg.ml-1（GSEM1.29）和0.63mg.ml-1（GSEM1.29），咳嗽阈值几何平均值分别为115mg.ml-1（GSEM1.20）和95.5mg.ml-1（GSEM1.35）。哮喘患者的PC 20 FEV 1显著低于正常人（p <0.01），但咳嗽阈值在两者之间无差异。正常人和哮喘患者的咳嗽阈值与PC 20 FEV 1无明显相关性。这些结果表明，咳嗽敏感性不直接相关的支气管反应性在正常和哮喘受试者。
We examined whether airway cough receptor sensitivity correlates to nonspecific bronchial responsiveness. We measured cough threshold, the lowest concentration of inhaled tartaric acid eliciting five or more coughs, and the provocative concentration of methacholine producing a 20% fall in forced expiratory volume in one second (PC20FEV1) in 38 normal and 11 asthmatic subjects. All subjects were nonsmokers. The geometric mean value of PC20FEV1 was 25.7 mg.ml-1 (GSEM1.29) and 0.63 mg.ml-1 (GSEM1.29) and the geometric mean value of the cough threshold was 115 mg.ml-1 (GSEM1.20) and 95.5 mg.ml-1 (GSEM1.35) in normal and asthmatic subjects, respectively. The PC20FEV1 was significantly (p less than 0.01) lower in asthmatics than in normals but the cough threshold did not differ between them. No significant correlation was observed between the cough threshold and the PC20FEV1 in normal subjects or in asthmatics. These results indicate that cough sensitivity does not directly correlate to bronchial responsiveness in normal and asthmatic subjects.
DOI：
--
发表时间：
1984-02
期刊：
The American review of respiratory disease
影响因子：
--
作者：
W. Eschenbacher;H. Boushey;D. Sheppard
通讯作者：
W. Eschenbacher;H. Boushey;D. Sheppard