MR Fingerprinting with b-Tensor Encoding for Simultaneous Quantification of Relaxation and Diffusion in a Single Scan.
MR Fingerprinting with b-Tensor Encoding for Simultaneous Quantification of Relaxation and Diffusion in a Single Scan.
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DOI：
10.1002/mrm.29352
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发表时间：
2022-11
影响因子：
3.3
通讯作者：
Ma, Dan
中科院分区：
文献类型：
--
作者：
Afzali, Maryam;Mueller, Lars;Sakaie, Ken;Hu, Siyuan;Chen, Yong;Szczepankiewicz, Filip;Griswold, Mark A.;Jones, Derek K.;Ma, Dan
关键词：
尽管弛豫和扩散成像都对组织微观结构敏感，但研究报告单独使用弛豫或传统扩散来表征组织微观结构的灵敏度和鲁棒性有限。最近，研究表明，张量值扩散编码和关节松弛扩散量化可以更可靠地量化隔室特定的微观结构特性。然而，获取此类数据的扫描时间可能令人望而却步。在这里，我们的目标是在临床可行的时间内使用 MR 指纹 (MRF) 和 b 张量编码同时量化松弛和扩散。我们开发了具有线性和球形 b 张量编码（LTE 和 STE）的多维 MRF 扫描 (mdMRF)，以通过单次扫描同时量化 T1、T2 和 ADC 图。比较了使用 LTE 和 STE 的 mdMRF 的图像质量、准确性和扫描效率。此外，我们研究了不同序列设计对信号错误的鲁棒性及其对图谱的影响。从 mdMRF 扫描得出的 T1 和 T2 图具有始终如一的高图像质量，而 ADC 图对不同的序列设计很敏感。值得注意的是，具有外围脉冲门控的基于快速成像稳态进动 (FISP) 的 mdMRF 扫描提供了最佳的 ADC 图，且没有图像失真和阴影伪影。我们证明了通过大约 24 秒/切片的单次 mdMRF 扫描同时量化 T1、T2 和 ADC 图的可行性。地图质量和定量值与参考扫描一致。 单击此处进行作者与读者讨论
Although both relaxation and diffusion imaging are sensitive to tissue microstructure, studies have reported limited sensitivity and robustness of using relaxation or conventional diffusion alone to characterize tissue microstructure. Recently, it has been shown that tensor‐valued diffusion encoding and joint relaxation‐diffusion quantification enable more reliable quantification of compartment‐specific microstructural properties. However, scan times to acquire such data can be prohibitive. Here, we aim to simultaneously quantify relaxation and diffusion using MR fingerprinting (MRF) and b‐tensor encoding in a clinically feasible time. We developed multidimensional MRF scans (mdMRF) with linear and spherical b‐tensor encoding (LTE and STE) to simultaneously quantify T1, T2, and ADC maps from a single scan. The image quality, accuracy, and scan efficiency were compared between the mdMRF using LTE and STE. Moreover, we investigated the robustness of different sequence designs to signal errors and their impact on the maps. T1 and T2 maps derived from the mdMRF scans have consistently high image quality, while ADC maps are sensitive to different sequence designs. Notably, the fast imaging steady state precession (FISP)‐based mdMRF scan with peripheral pulse gating provides the best ADC maps that are free of image distortion and shading artifacts. We demonstrated the feasibility of quantifying T1, T2, and ADC maps simultaneously from a single mdMRF scan in around 24 s/slice. The map quality and quantitative values are consistent with the reference scans. Click here for author‐reader discussions
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使用自由的笛卡尔回声平面时间解决采集和关节幅度以及相位约束重建的无变形扩散成像。
影响因子：
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通讯作者：
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