Phencyclidine-like behavioral effects in pigeons induced by systemic administration of the excitatory amino acid antagonist, 2-amino-5-phosphonovalerate.
Phencyclidine-like behavioral effects in pigeons induced by systemic administration of the excitatory amino acid antagonist, 2-amino-5-phosphonovalerate.
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全身给予兴奋性氨基酸拮抗剂 2-氨基-5-磷酸戊酸可诱导鸽子出现类似苯环己哌啶的行为效应。
DOI：
10.1016/0024-3205(86)90285-7
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发表时间：
1986
期刊：
影响因子：
6.1
通讯作者：
Ornstein,P
中科院分区：
文献类型：
--
作者：
Koek,W;Woods,JH;Ornstein,P
一种选择性n -甲基- d -天冬氨酸拮抗剂，dl -2-氨基-5-磷酸戊酸，在鸽子肌肉注射时，被发现产生pcp样的猝厥、鉴别刺激效应和刻板操作反应。这些结果支持了一种假设，即pcp类药物的行为影响至少部分是由于使用n -甲基- d -天冬氨酸偏好受体的兴奋性氨基酸突触的神经传递减少。
A selective N-methyl-D-aspartate antagonist, DL-2-amino-5-phosphonovalerate, was found to produce PCP-like catalepsy, discriminative stimulus effects, and stereotyped operant responding in pigeons when administered intramuscularly. These results support the hypothesis that the behavioral effects of PCP-like drugs result at least in part from reduced neurotransmission at excitatory amino acid synapses utilizing N-methyl-D-aspartate preferring receptors.
苯环己哌啶诱导的鸽子僵直症：特异性和立体选择性。
影响因子：
5
作者：
Koek,W;Woods,JH;Rice,KC;Jacobson,AE;Huguenin,PN;BurkeJr,TR
通讯作者：
BurkeJr,TR