Platelet factor 4 inhibits human hair follicle growth and promotes androgen receptor expression in human dermal papilla cells
Platelet factor 4 inhibits human hair follicle growth and promotes androgen receptor expression in human dermal papilla cells
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血小板因子4抑制人毛囊生长并促进人真皮乳头细胞雄激素受体表达
作者：
Sha Ke;Chen Mengting;Liu Fangfen;Xu San;Wang Ben;Peng Qinqin;Zhang Yiya;Xie Hongfu;Li Ji;Deng Zhili
富血小板血浆（PRP）最近已被报道为一种潜在的治疗脱发的方法，如雄激素性脱发，但确切的机制和该配方的特定成分的影响仍然在很大程度上未知。在这项研究中，我们发现血小板因子4（PF 4），PRP的一个组成部分，显着抑制人毛囊的生长和抑制人毛乳头细胞（hDPC）的增殖。此外，我们的研究结果表明，PF 4上调雄激素受体（AR）在人毛乳头细胞在体外和通过毛囊器官培养。在所研究的毛发生长促进和DP特征基因中，PF 4降低Wnt 5a、Wnt 10 b、LEF 1、HEY 1和IGF-1的表达，增加DKK 1的表达，但不影响BMP 2和BMP 4的表达。总的来说，我们的数据表明，PF 4可能通过上调雄激素受体信号传导和调节毛发生长相关基因来抑制人类毛囊生长，这为PRP在治疗脱发中的应用和优化提供了发人深省的见解。
Platelet-rich plasma (PRP) has been reported recently as a potential therapeutic approach for alopecia, such as androgenetic alopecia, but the exact mechanisms and effects of specific components of this recipe remain largely unknown. In this study, we identified that platelet factor 4 (PF4), a component of PRP, significantly suppressed human hair follicle growth and restrained the proliferation of human dermal papilla cells (hDPCs). Furthermore, our results showed that PF4 upregulated androgen receptor (AR) in human dermal papilla cells in vitro and via hair follicle organ culture. Among the hair growth-promoting and DP-signature genes investigated, PF4 decreased the expression of Wnt5a, Wnt10b, LEF1, HEY1 and IGF-1, and increased DKK1 expression, but did not affect BMP2 and BMP4 expression. Collectively, Our data demonstrate that PF4 suppresses human hair follicle growth possibly via upregulating androgen receptor signaling and modulating hair growth-associated genes, which provides thought-provoking insights into the application and optimization of PRP in treating hair loss.
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影响因子：
5.6
作者：
Gentile P;Cole JP;Cole MA;Garcovich S;Bielli A;Scioli MG;Orlandi A;Insalaco C;Cervelli V
通讯作者：
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影响因子：
21.3
作者：
通讯作者：
--
影响因子：
1.4
作者：
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通讯作者：
Xuyan Chen;Renpin Chen;Ruifang Jin;Zhiming Huang
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影响因子：
5.5
作者：
Deng, Zhili;Lei, Xiaohua;Duan, Enkui
通讯作者：
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影响因子：
6.5
作者：
Plikus, Maksim V.
通讯作者：
Plikus, Maksim V.