Regional brain distribution of translocator protein using [(11)C]DPA-713 PET in individuals infected with HIV.
Regional brain distribution of translocator protein using [(11)C]DPA-713 PET in individuals infected with HIV.
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DOI：
10.1007/s13365-014-0239-5
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发表时间：
2014-06
影响因子：
3.2
通讯作者：
Pomper MG
中科院分区：
文献类型：
--
作者：
Coughlin JM;Wang Y;Ma S;Yue C;Kim PK;Adams AV;Roosa HV;Gage KL;Stathis M;Rais R;Rojas C;McGlothan JL;Watkins CC;Sacktor N;Guilarte TR;Zhou Y;Sawa A;Slusher BS;Caffo B;Kassiou M;Endres CJ;Pomper MG
成像转运蛋白（TSPO）的大脑分布，神经胶质细胞活化和神经炎症的假定生物标志物，可以通过揭示与神经认知缺陷相关的区域异常来告知HIV感染者的管理，并实现非侵入性治疗监测。使用第二代TSPO靶向放射性示踪剂[11 C]DPA-713，我们进行了一项正电子发射断层扫描（PET）研究，比较了12名健康受试者与23名接受联合抗逆转录病毒疗法（cART）有效治疗的HIV感染者的大脑。与年龄匹配的健康对照受试者的PET数据相比，HIV感染个体的[11 C]DPA-713 PET显示，相对于整体灰质VT，白色物质、扣带回皮质和缘上回的分布容积（VT）比显著更高，表明易感区域存在局部胶质细胞活化。区域TSPO异常在神经无症状HIV受试者的子队列中是明显的，并且额叶皮层内VT比率的增加与受HIV相关痴呆影响的个体特别相关。这些发现是通过采用灰质标准化方法进行PET数据量化来实现的，该方法提高了重测重复性、健康对照队列内的类内相关性以及发现异常区域发现的灵敏度。
Imaging the brain distribution of translocator protein (TSPO), a putative biomarker for glial cell activation and neuroinflammation, may inform management of individuals infected with HIV by uncovering regional abnormalities related to neurocognitive deficits and enable non-invasive therapeutic monitoring. Using the second-generation TSPO-targeted radiotracer, [11C]DPA-713, we conducted a positron emission tomography (PET) study to compare the brains of 12 healthy human subjects to those of 23 individuals with HIV who were effectively treated with combination antiretroviral therapy (cART). Compared to PET data from age-matched healthy control subjects, [11C]DPA-713 PET of individuals infected with HIV demonstrated significantly higher volume-of-distribution (VT) ratios in white matter, cingulate cortex, and supramarginal gyrus, relative to overall gray matter VT, suggesting localized glial cell activation in susceptible regions. Regional TSPO abnormalities were evident within a sub-cohort of neuro-asymptomatic HIV subjects, and an increase in the VT ratio within frontal cortex was specifically linked to individuals affected with HIV-associated dementia. These findings were enabled by employing a gray matter normalization approach for PET data quantification, which improved test–retest reproducibility, intra-class correlation within the healthy control cohort, and sensitivity of uncovering abnormal regional findings.
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影响因子：
3.2
作者：
Jucaite, Aurelija;Cselenyi, Zsolt;Farde, Lars
通讯作者：
Farde, Lars
影响因子：
3.2
作者：
Heaton, Robert K.;Franklin, Donald R.;Ellis, Ronald J.;McCutchan, J. Allen;Letendre, Scott L.;LeBlanc, Shannon;Corkran, Stephanie H.;Duarte, Nichole A.;Clifford, David B.;Woods, Steven P.;Collier, Ann C.;Marra, Christina M.;Morgello, Susan;Mindt, Monica Rivera;Taylor, Michael J.;Marcotte, Thomas D.;Atkinson, J. Hampton;Wolfson, Tanya;Gelman, Benjamin B.;McArthur, Justin C.;Simpson, David M.;Abramson, Ian;Gamst, Anthony;Fennema-Notestine, Christine;Jernigan, Terry L.;Wong, Joseph;Grant, Igor
通讯作者：
Grant, Igor
影响因子：
9.3
作者：
Brown, Amira K.;Fujita, Masahiro;Innis, Robert B.
通讯作者：
Innis, Robert B.
影响因子：
4.1
作者：
Churchill M;Nath A
通讯作者：
Nath A
影响因子：
9.9
作者：
Marder, K;Albert, SM;Epstein, LG
通讯作者：
Epstein, LG