Ultrasound strain mapping of the mouse Achilles tendon during passive dorsiflexion.
Ultrasound strain mapping of the mouse Achilles tendon during passive dorsiflexion.
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DOI：
10.1016/j.jbiomech.2021.110920
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发表时间：
2022-02
影响因子：
2.4
通讯作者：
Buckley, Mark R.
中科院分区：
文献类型：
--
作者：
Mora, Keshia E.;Mlawer, Samuel J.;Bae, Albert J.;Richards, Michael S.;Loiselle, Alayna E.;Buckley, Mark R.
在植入骨骼之前，许多健康的肌腱都会受到附近骨骼结构的冲击。然而，超生理水平的撞击与附着性肌腱病有关。不幸的是，撞击和肌腱病理之间联系的潜在机制仍然知之甚少，部分原因是缺乏临床相关部位撞击的良好动物模型。作为建立肌腱过度撞击模型的第一步，本研究的目的是描述被动背屈下小鼠跟腱插入的机械应变环境，并证实--像人类一样--小鼠在背屈脚踝的位置从跟骨(脚后跟骨)经历肌腱插入的撞击。基于人类先前的工作，我们假设在背屈时，由于跟骨撞击，小鼠跟腱附着处将经历高水平的横向压缩应变。使用定制的加载平台来实施被动背屈，而位于跟腱上的超声换能器则采集射频图像。然后利用非刚体图像配准算法对采集到的超声图像序列进行横向压缩应变映射。我们的结果表明，在被动背屈时，整个跟腱产生横向压缩应变，且在肌腱附着处的应变值明显大于在中间质处的应变值。此外，随着背屈角度的增加，跟腱内的横向压缩应变也随之增加。这项研究加深了我们对跟腱在生理相关条件下独特的机械载荷环境的理解。
Immediately prior to inserting into bone, many healthy tendons experience impingement from nearby bony structures. However, super-physiological levels of impingement are implicated in insertional tendinopathies. Unfortunately, the mechanisms underlying the connection between impingement and tendon pathology remain poorly understood, in part due to the shortage of well-characterized animal models of impingement at clinically relevant sites. As a first step towards developing a model of excessive tendon impingement, the objective of this study was to characterize the mechanical strain environment in the mouse Achilles tendon insertion under passive dorsiflexion and confirm that – like humans – mice experience impingement of the tendon insertion from the calcaneus (heel bone) in dorsiflexed ankle positions. Based on previous work in humans, we hypothesized that during dorsiflexion, the mouse Achilles tendon insertion would experience high levels of transverse compressive strain due to calcaneal impingement. A custom-built loading platform was used to apply passive dorsiflexion, while an ultrasound transducer positioned over the Achilles tendon captured radiofrequency images. A non-rigid image registration algorithm was then used to map the transverse compressive strain based on the acquired ultrasound image sequences. Our results demonstrate that during passive dorsiflexion, transverse compressive strains were produced throughout the Achilles tendon, with significantly larger strain magnitudes at the tendon insertion than at the midsubstance. Furthermore, there was increasing transverse compressive strain observed within the Achilles tendon as a function of increasing dorsiflexion angle. This study enhances our understanding of the unique mechanical loading environment of the Achilles tendon under physiologically relevant conditions.
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DOI：
10.1002/jor.23338
发表时间：
2017-04
期刊：
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
影响因子：
--
作者：
Chimenti RL;Bucklin M;Kelly M;Ketz J;Flemister AS;Richards MS;Buckley MR
通讯作者：
Buckley MR
影响因子：
5
作者：
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通讯作者：
Tirman, PFJ
影响因子：
2.7
作者：
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通讯作者：
Barrass, Victoria
DOI：
10.1016/j.jmbbm.2015.08.022
发表时间：
2016-01
影响因子：
3.9
作者：
Bah I;Kwak ST;Chimenti RL;Richards MS;P Ketz J;Samuel Flemister A;Buckley MR
通讯作者：
Buckley MR
影响因子：
3.9
作者：
KOOB, TJ;CLARK, PE;VOGEL, KG
通讯作者：
VOGEL, KG