Reduced IL-2 expression in NOD mice leads to a temporal increase in CD62Llo FoxP3+ CD4+ T cells with limited suppressor activity.
Reduced IL-2 expression in NOD mice leads to a temporal increase in CD62Llo FoxP3+ CD4+ T cells with limited suppressor activity.
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DOI：
10.1002/eji.201040890
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发表时间：
2011-05
影响因子：
5.4
通讯作者：
Tisch, Roland
中科院分区：
文献类型：
--
作者：
Goudy, Kevin S.;Johnson, Mark C.;Garland, Alaina;Li, Chengwen;Samulski, Richard J.;Wang, Bo;Tisch, Roland
IL-2在表达FoxP 3的调节性T细胞（FoxP 3 +Treg）的诱导和维持中起关键作用。IL-2的表达减少与T细胞介导的自身免疫性疾病有关，如1型糖尿病（T1 D），其中FoxP 3 +Treg和致病性T效应子之间存在不平衡。我们通过比较野生型NOD小鼠与C57 BL/6衍生的疾病抗性Il 2等位基因同源的动物并且其中IL-2的T细胞分泌增加（NOD.B6Idd3），研究了IL-2对FoxP 3 +Treg失调的贡献。尽管NOD小鼠由于CD 62 LLOFoxP 3 + Treg的增加而表现出CD 62 LHIFoxP 3 + Treg频率的进行性下降，但CD 62 LHIFoxP 3 +Treg维持在NOD. B6 Idd 3小鼠的胰腺淋巴结和胰岛中。值得注意的是，与NOD小鼠相比，NOD.B6Idd3的胰岛中增殖的CD 62 LHIFoxP 3 +Treg的频率升高。体内IL-2水平的增加也导致NOD小鼠中更大量的CD 62 LHIFoxP 3 +Treg。这些结果表明，IL-2通过调节CD 62 LLO和CD 62 LHI FoxP 3 + Treg之间的平衡来影响FoxP 3 + Treg库的抑制活性。在NOD小鼠中，IL-2表达减少导致非抑制性CD 62 LLOFoxP 3 +Treg增加，这又与增殖受限的CD 62 LHIFoxP 3 +Treg库相关。
IL-2 plays a critical role in the induction and maintenance of FoxP3-expressing regulatory T cells (FoxP3+Treg). Reduced expression of IL-2 is linked to T cell-mediated autoimmune diseases such as Type 1 diabetes (T1D), in which an imbalance between FoxP3+Treg and pathogenic T effectors exists. We investigated the contribution of IL-2 to dysregulation of FoxP3+Treg by comparing wildtype NOD mice with animals congenic for a C57BL/6-derived disease resistant Il2 allele and in which T cell secretion of IL-2 is increased (NOD.B6Idd3). Whereas NOD mice exhibited a progressive decline in the frequency of CD62LHIFoxP3+Treg due to an increase in CD62LLOFoxP3+Treg, CD62LHIFoxP3+Treg were maintained in the pancreatic lymph nodes and islets of NOD.B6Idd3 mice. Notably, the frequency of proliferating CD62LHIFoxP3+Treg was elevated in the islets of NOD.B6Idd3 versus NOD mice. Increasing levels of IL-2 in vivo also resulted in larger numbers of CD62LHIFoxP3+Treg in NOD mice. These results demonstrate that IL-2 influences the suppressor activity of the FoxP3+Treg pool by regulating the balance between CD62LLO and CD62LHI FoxP3+Treg. In NOD mice reduced IL-2 expression leads to an increase in nonsuppressive CD62LLOFoxP3+Treg, which in turn correlates with a pool of CD62LHIFoxP3+Treg with limited proliferation.
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影响因子：
3.7
作者：
Datta S;Sarvetnick NE
通讯作者：
Sarvetnick NE
影响因子：
4.4
作者：
Clough, Louise E.;Wang, Chun Jing;Walker, Lucy S. K.
通讯作者：
Walker, Lucy S. K.
影响因子：
7.7
作者：
Brusko, TM;Wasserfall, CH;Atkinson, MA
通讯作者：
Atkinson, MA
DOI：
10.1084/jem.20051409
发表时间：
2005-11-21
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Chen Z;Herman AE;Matos M;Mathis D;Benoist C
通讯作者：
Benoist C
影响因子：
56.9
作者：
CHEN, YH;KUCHROO, VK;WEINER, HL
通讯作者：
WEINER, HL