Mesoporous Silica Nanoparticles: Properties and Strategies for Enhancing Clinical Effect.
Mesoporous Silica Nanoparticles: Properties and Strategies for Enhancing Clinical Effect.
复制标题
介孔二氧化硅纳米颗粒：性能和提高临床效果的策略。
DOI：
10.3390/pharmaceutics13040570
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发表时间：
2021-04-17
期刊：
影响因子：
5.4
通讯作者：
McNally LR
中科院分区：
文献类型：
--
作者：
Frickenstein AN;Hagood JM;Britten CN;Abbott BS;McNally MW;Vopat CA;Patterson EG;MacCuaig WM;Jain A;Walters KB;McNally LR
由于介孔二氧化硅纳米颗粒（MSNs）的治疗潜力，这些被广泛研究作为一种新的方法，以改善临床结果。MSNs拥有令人印象深刻的配方和修改，当用于在临床前模型中识别或治疗无数恶性疾病时，MSNs表现出显着的体内功效。随着MSN继续向临床试验过渡，有必要彻底了解有效MSN的特征。这篇综述强调了MSN理解和技术的最新发现和进展。特别关注使用MSN的癌症治疗方法。MSN的大小，形状和表面性质等特点进行了讨论，有效的纳米医学实践和预计的临床疗效。此外，与MSN一起使用的肿瘤靶向选择与关于主动靶向分子的广泛讨论一起提出。进一步解释了降低MSN毒性、改善位点特异性递送和控制负载分子释放的方法。该领域面临的挑战和翻译到临床环境的同时，提出了继续调查的潜在途径。
Due to the theragnostic potential of mesoporous silica nanoparticles (MSNs), these were extensively investigated as a novel approach to improve clinical outcomes. Boasting an impressive array of formulations and modifications, MSNs demonstrate significant in vivo efficacy when used to identify or treat myriad malignant diseases in preclinical models. As MSNs continue transitioning into clinical trials, a thorough understanding of the characteristics of effective MSNs is necessary. This review highlights recent discoveries and advances in MSN understanding and technology. Specific focus is given to cancer theragnostic approaches using MSNs. Characteristics of MSNs such as size, shape, and surface properties are discussed in relation to effective nanomedicine practice and projected clinical efficacy. Additionally, tumor-targeting options used with MSNs are presented with extensive discussion on active-targeting molecules. Methods for decreasing MSN toxicity, improving site-specific delivery, and controlling release of loaded molecules are further explained. Challenges facing the field and translation to clinical environments are presented alongside potential avenues for continuing investigations.
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影响因子：
9.5
作者：
Abstiens, Kathrin;Gregoritza, Manuel;Goepferich, Achim M.
通讯作者：
Goepferich, Achim M.
影响因子：
15
作者：
Cheng, Chi-An;Chen, Wei;Zink, Jeffrey I.
通讯作者：
Zink, Jeffrey I.
影响因子：
5
作者：
Beagan AM;Alghamdi AA;Lahmadi SS;Halwani MA;Almeataq MS;Alhazaa AN;Alotaibi KM;Alswieleh AM
通讯作者：
Alswieleh AM
影响因子：
12.4
作者：
Chen K;Chen X
通讯作者：
Chen X
DOI：
10.1073/pnas.1608247113
发表时间：
2016-07-19
影响因子：
11.1
作者：
Anderson, Michael;Moshnikova, Anna;Andreev, Oleg A.
通讯作者：
Andreev, Oleg A.