Folic Acid-Terminated Poly(2-Diethyl Amino Ethyl Methacrylate) Brush-Gated Magnetic Mesoporous Nanoparticles as a Smart Drug Delivery System.
Folic Acid-Terminated Poly(2-Diethyl Amino Ethyl Methacrylate) Brush-Gated Magnetic Mesoporous Nanoparticles as a Smart Drug Delivery System.
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DOI：
10.3390/polym13010059
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发表时间：
2020-12-25
期刊：
影响因子：
5
通讯作者：
Alswieleh AM
中科院分区：
文献类型：
--
作者：
Beagan AM;Alghamdi AA;Lahmadi SS;Halwani MA;Almeataq MS;Alhazaa AN;Alotaibi KM;Alswieleh AM
目前，化疗是治疗各种癌症的重要方法。尽管如此，它仍有许多局限性，例如肿瘤选择性差和多药耐药性。有必要通过引入旨在减少副作用和耐药性的靶向药物递送系统来改进这种治疗方法。本工作的目的是开发pH敏感的纳米载体含有磁性介孔二氧化硅纳米粒子（MMSNs）涂有pH响应聚合物的肿瘤靶向药物通过叶酸受体。2-通过表面引发ARGET原子转移自由基聚合（ATRP），成功地将甲基丙烯酸二乙氨基乙酯（DEAEMA）接枝到平均粒径为180 nm的MMSNs上。聚（2-（二乙基氨基）乙基甲基丙烯酸酯）（PDEAEMA）刷的端基转化为胺，然后与叶酸（FA）作为靶向剂的共价键。通过X射线光电子能谱（XPS）证实FA缀合到纳米颗粒表面。用动态光散射（DLS）研究了PDEAEMA刷的pH响应行为。纳米颗粒的平均直径范围为约100 nm。350 nm在基本介质中至约650在酸性溶液中。多功能pH敏感磁性介孔纳米粒子负载抗癌药物（阿霉素），以研究其容量和长循环时间。在累积释放模式中，阿霉素（DOX）从纳米系统中释放约为100 μ g。20%，当颗粒暴露于酸性介质时，与ca. 5%的基础媒体。该纳米系统具有优异的生物相容性，并且当暴露于MCF-7和-MCF-7 ADR细胞时具有最小的毒性。
Currently, chemotherapy is an important method for the treatment of various cancers. Nevertheless, it has many limitations, such as poor tumour selectivity and multi-drug resistance. It is necessary to improve this treatment method by incorporating a targeted drug delivery system aimed to reduce side effects and drug resistance. The present work aims to develop pH-sensitive nanocarriers containing magnetic mesoporous silica nanoparticles (MMSNs) coated with pH-responsive polymers for tumour-targeted drug delivery via the folate receptor. 2-Diethyl amino ethyl methacrylate (DEAEMA) was successfully grafted on MMSNs via surface initiated ARGET atom transfer radical polymerization (ATRP), with an average particle size of 180 nm. The end groups of poly (2-(diethylamino)ethyl methacrylate) (PDEAEMA) brushes were converted to amines, followed by a covalent bond with folic acid (FA) as a targeting agent. FA conjugated to the nanoparticle surface was confirmed by X-ray photoelectron spectroscopy (XPS). pH-Responsive behavior of PDEAEMA brushes was investigated by Dynamic Light Scattering (DLS). The nanoparticles average diameters ranged from ca. 350 nm in basic media to ca. 650 in acidic solution. Multifunctional pH-sensitive magnetic mesoporous nanoparticles were loaded with an anti-cancer drug (Doxorubicin) to investigate their capacity and long-circulation time. In a cumulative release pattern, doxorubicin (DOX) release from nano-systems was ca. 20% when the particle exposed to acidic media, compared to ca. 5% in basic media. The nano-systems have excellent biocompatibility and are minimally toxic when exposed to MCF-7, and -MCF-7 ADR cells.
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影响因子：
3.2
作者：
Ji, Jingou;Wu, Danjun;Xu, Yi
通讯作者：
Xu, Yi
影响因子：
19
作者：
Oh, Jae-Min;Choi, Soo-Jin;Choy, Jin-Ho
通讯作者：
Choy, Jin-Ho
影响因子：
78.5
作者：
Chabner, BA;Roberts, TG
通讯作者：
Roberts, TG
影响因子：
5
作者：
Beagan A;Lahmadi S;Alghamdi A;Halwani M;Almeataq M;Alhazaa A;Alotaibi K;Alswieleh A
通讯作者：
Alswieleh A
影响因子：
4.6
作者：
Alswieleh, Abdullah M.;Beagan, Abeer M.;Almeataq, Mohammed S.
通讯作者：
Almeataq, Mohammed S.