ZNF671 methylation test in cervical scrapings for cervical intraepithelial neoplasia grade 3 and cervical cancer detection.
ZNF671 methylation test in cervical scrapings for cervical intraepithelial neoplasia grade 3 and cervical cancer detection.
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DOI：
10.1016/j.xcrm.2023.101143
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发表时间：
2023-08-15
影响因子：
14.3
通讯作者：
Li, Qing
中科院分区：
文献类型：
--
作者：
Zhu, Peng;Xiong, Jing;Yuan, Ding;Li, Xiang;Luo, Lili;Huang, Ju;Wang, Binbin;Nie, Quanfang;Wang, Shuli;Dang, Liying;Chen, Yan;Li, Shu;An, Yuhan;Yang, Li;Liu, Rong;He, Yanping;Li, Xiong;Chen, Puxiang;Zhou, Honghao;Li, Qing
对高危人乳头瘤病毒（hrHPV）阳性妇女进行有效的分诊是必要的，以避免不必要的转诊和过度治疗。分子分诊检测最近开始影响宫颈上皮内瘤变3级（CIN3）或宫颈癌（CC）（称为CIN3+）的检测。我们发现锌指蛋白671甲基化（ZNF671m）检测在训练集中HPV16/18基因分型、配对盒基因1甲基化（PAX1m）和ZNF671m的所有单分子分类测试中对CIN3+的检测都具有优越的性能。在验证集中的391名hrHPV+女性中，使用ZNF671m检测代替Thinprep细胞学检测（TCT）作为单一分诊策略或与HPV16/18基因分型联合分诊策略，对CIN3+检测具有相当的敏感性，但更高的特异性。hrHPV -状态但检测到CIN3+的妇女很少受到关注。我们发现，在hrHPV阴性患者中使用ZNF671m进行分诊可以进一步降低阴性结果后CIN3+的风险。ZNF671甲基化试验在CIN3+检测方面表现优异ZNF671甲基化试验是细胞学分类的一种有希望的替代方法ZNF671甲基化试验可降低hrHPV女性的CIN3+风险- ZNF671甲基化试验在医疗资源贫乏的地区更容易获得Zhu等人评估ZNF671甲基化试验在CIN3+检测方面的性能。ZNF671甲基化检测是细胞学分类的一种很有前途的替代方法。此外，通过ZNF671甲基化试验进行分诊可进一步降低hrHPV阴性妇女的CIN3+风险。
Effective triage of high-risk human papillomavirus (hrHPV)+ women is warranted to avoid unnecessary referral and overtreatment. Molecular triage tests have recently begun to impact cervical intraepithelial neoplasia grade 3 (CIN3) or cervical cancer (CC), termed CIN3+, detection. We find that zinc finger protein 671 methylation (ZNF671m) test has superior performance for CIN3+ detection in all single molecular triage tests, including HPV16/18 genotyping, paired box gene 1 methylation (PAX1m), and ZNF671m, in the training set. Using ZNF671m test instead of Thinprep cytologic test (TCT) as a single triage strategy or as a combined triage strategy with HPV16/18 genotyping has achieved comparable sensitivity but higher specificity for CIN3+ detection among 391 hrHPV+ women in the validation set. Little attention has been paid to the women with hrHPV− status but detected CIN3+. We find that the CIN3+ risk after a negative result could be reduced further by triage using ZNF671m in hrHPV− patients. ZNF671 methylation test shows superior performance for CIN3+ detection ZNF671 methylation test can be a promising alternative to cytology triage Triage by ZNF671 methylation test reduces the CIN3+ risk in hrHPV− women ZNF671 methylation test is more accessible in areas with poor medical resources Zhu et al. evaluate the performance of ZNF671 methylation test for CIN3+ detection. ZNF671 methylation test can be a promising alternative to cytology triage. In addition, triage by ZNF671 methylation test reduces the CIN3+ risk further in hrHPV− women.
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DOI：
10.1097/igc.0000000000000155
发表时间：
2014-06-01
影响因子：
4.8
作者：
Kan, Yuen-Yee;Liou, Yu-Ligh;Liao, Cheng-I
通讯作者：
Liao, Cheng-I
影响因子：
3.1
作者：
Brentnall, Adam R.;Vasiljevic, Natasa;Lorincz, Attila T.
通讯作者：
Lorincz, Attila T.
影响因子：
120.7
作者：
Kulasingam, SL;Hughes, JP;Koutsky, LA
通讯作者：
Koutsky, LA
影响因子：
7.2
作者：
Moscicki AB;Ma Y;Wibbelsman C;Darragh TM;Powers A;Farhat S;Shiboski S
通讯作者：
Shiboski S
DOI：
10.5146/tjpath.2019.01473
发表时间：
2020
期刊：
Turk patoloji dergisi
影响因子：
--
作者：
Özcan Z;Kimiloğlu E;Iğdem AA;Erdoğan N
通讯作者：
Erdoğan N