Comparison of the Diagnostic Utility of Manual Screening and the ThinPrep Imaging System in Liquid-Based Cervical Cytology.
Comparison of the Diagnostic Utility of Manual Screening and the ThinPrep Imaging System in Liquid-Based Cervical Cytology.
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DOI：
10.5146/tjpath.2019.01473
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Erdoğan N
中科院分区：
文献类型：
--
作者：
Özcan Z;Kimiloğlu E;Iğdem AA;Erdoğan N
目的：比较ThinPrep手工方法（TPMM）和ThinPrep自动方法（TPAM）液基细胞学诊断结果，并介绍两种方法的优缺点。材料和方法：由一名盲法研究人员手动和ThinPrep自动方法对2015年人工筛选和存档的1500份随机ThinPrep Pap试验进行审查。结果：与TPMM相比，TPAM对ASCUS（未确定意义的非典型鳞状细胞）的检出率提高了83.3%，并且与参考结果相比，TPAM的准确性高于TPMM。我们还注意到，TPAM使LSIL（低级别鳞状上皮内病变）的发生率增加了33.3%，HSIL（高级别鳞状上皮内病变）的发生率增加了20%。TPAM与参考细胞学诊断的一致性最好。TPAM的敏感性较高，两种方法的特异性相似。TPAM的假阳性率高于TPMM，而TPMM的假阴性率高于TPMM。我们确定TPAM每次涂片的筛查时间增加30%。然而，系统对许多样品的排斥，特别是由于气泡的存在，是TPAM的局限性。结论：TPAM比TPMM有优点，但也有局限性和假阳性率高的缺点。TPAM应辅以手工方法，以降低假阳性率。
Objective: To compare the diagnostic results of the ThinPrep manual method (TPMM) and ThinPrep automated method (TPAM) in liquid-based cytology and present the advantages and disadvantages of both methods. Material and Method: A total of 1.500 randomized ThinPrep Pap tests that were screened manually and archived in 2015 were reviewed by a blinded researcher manually and by the ThinPrep automatic method. Results: There was a 83.3% increase in the detection of ASCUS (Atypical squamous cells of undetermined significance) with the TPAM compared to the TPMM, and with respect to the reference results, the accuracy was higher for the TPAM than for the TPMM. We also noted a 33.3% increase in the rate of LSIL (Low grade squamous intraepithelial lesion) and 20% increase in the rate of HSIL (High grade squamous intraepithelial lesion) by the TPAM. Concordance was best between the TPAM and reference cytologic diagnoses. The sensitivity was higher for the TPAM and the specificity was similar for both methods. The false positive rate was higher for the TPAM than the TPMM but the false negative rate was higher for the TPMM. We determined a 30% gain in screening time per smear by the TPAM. However, rejection of many samples by the system, especially because of air bubbles, was a limitation of the TPAM. Conclusion: The TPAM has advantages over the TPMM as well as disadvantages such as limiting features and a high false positive rate. The TPAM should be supported by the manual method to decrease the false positive rate.
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影响因子：
3.4
作者：
Strander, Bjoern;Andersson-Elistrom, Agneta;Ryd, Walter
通讯作者：
Ryd, Walter
影响因子：
51.1
作者：
Kitchener, Henry C.;Blanks, Roger;Moss, Sue
通讯作者：
Moss, Sue
DOI：
10.1111/j.1471-0528.2010.02650.x
发表时间：
2010-08-01
影响因子：
5.8
作者：
Castle, P. E.;Bulten, J.;Arbyn, M.
通讯作者：
Arbyn, M.
影响因子：
1.3
作者：
Tripathy K;Misra A;Ghosh JK
通讯作者：
Ghosh JK
影响因子：
0.6
作者：
Bak Mihaly;Seberne Ell Maria;Szentirmay Zoltan
通讯作者：
Szentirmay Zoltan