Effects of supplemental vitamin D and calcium on normal colon tissue and circulating biomarkers of risk for colorectal neoplasms.
Effects of supplemental vitamin D and calcium on normal colon tissue and circulating biomarkers of risk for colorectal neoplasms.
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DOI：
10.1016/j.jsbmb.2015.01.010
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发表时间：
2015-04
影响因子：
4.1
通讯作者：
Bostick, Roberd M.
中科院分区：
文献类型：
--
作者：
Bostick, Roberd M.
这篇简短的综述基于第17届维生素D研讨会的一次应邀演讲，旨在总结作者的一系列研究，这些研究针对澄清和/或开发维生素D和钙以及作为人类结直肠癌预防药物的相互交织的任务，了解这些药物可能降低疾病风险的机制，以及开发结直肠癌风险的可治疗的生物标记物。综述了维生素D和钙降低结直肠癌风险的生物学真实性、观察性和临床试验证据、结直肠癌风险前生物标记物的发展，以及作者研究小组关于维生素D和钙调节这些生物标记物有效性的临床试验结果。对于后者，我们在一项随机、双盲、安慰剂对照、2×2因子设计的临床试验中，测试了每天服用800IU(20微克)维生素D3和2.0克钙与安慰剂相比，在6个月内调节正常结肠组织和基于循环假说的结直肠肿瘤风险生物标志物的有效性(n=92)。采用免疫组织化学结合定量图像分析的方法检测正常直肠黏膜活检组织中的组织生物标志物，并用酶联免疫分析法检测一组循环炎症标志物。与安慰剂组相比，维生素D组的组织比例显著增加，Bax(51%)、p21(141%)、APC(48%)、E-钙粘蛋白(78%)、MSH2(179%)、CaSR(39%)和CYP27B1(159%)。在血液中，概要炎症z分数在统计学上显著降低了77%。钙的发现与维生素D相似。这些发现表明，补充维生素D3或钙可以有利地调节多个正常结肠组织和基于循环假说的循环生物标记物，这些生物标志物是散发性结肠腺瘤患者结直肠癌风险的基础。
This brief review, based on an invited presentation at the 17th Workshop on Vitamin D, is to summarize a line of the author’s research that has been directed at the intertwined missions of clarifying and/or developing vitamin D and calcium and as preventive agents against colorectal cancer in humans, understanding the mechanisms by which these agents may reduce risk for the disease, and developing ‘treatable’ biomarkers of risk for colorectal cancer. The biological plausibility and observational and clinical trial evidence for vitamin D and calcium in reducing risk for colorectal neoplasms, the development of pre-neoplastic biomarkers of risk for colorectal neoplasms, and the clinical trial findings from the author’s research group on the efficacy of vitamin D and calcium in modulating these biomarkers are summarized. Regarding the latter, we tested the efficacy of 800 IU (20 µg) of vitamin D3 and 2.0g of calcium daily, alone and combined vs. placebo over 6 months on modulating normal colon tissue and circulating hypothesis-based biomarkers of risk for colorectal neoplasms in a randomized, double-blind, placebo-controlled, 2×2 factorial design clinical trial (n = 92). The tissue-based biomarkers were measured in biopsies of normal-appearing rectal mucosa using immunohistochemistry with quantitative image analysis, and a panel of circulating inflammation markers was measured using enzyme-linked immunoassays (ELISA). Statistically significant proportional tissue increases in the vitamin D group relative to the placebo group were found in bax (51%), p21 (141%), APC (48%), E-cadherin (78%), MSH2 (179%), the CaSR (39%), and CYP27B1 (159%). In blood, there was a 77% statistically significant decrease in a summary inflammation z-score. The findings for calcium were similar to those for vitamin D. These findings indicate that supplemental vitamin D3 or calcium can favorably modulate multiple normal colon tissue and circulating hypothesis-based biomarkers of risk for colorectal neoplasms in sporadic colorectal adenoma patients.
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影响因子：
158.5
作者：
Bertagnolli, Monica M.;Eagle, Craig J.;Hawk, Ernest T.
通讯作者：
Hawk, Ernest T.
DOI：
10.1158/1940-6207.capr-12-0292
发表时间：
2012-10
期刊：
Cancer prevention research (Philadelphia, Pa.)
影响因子：
--
作者：
Ahearn TU;Shaukat A;Flanders WD;Rutherford RE;Bostick RM
通讯作者：
Bostick RM
影响因子：
158.5
作者：
Baron, JA;Beach, M;Greenberg, ER
通讯作者：
Greenberg, ER
影响因子：
8.8
作者：
Boutron, MC;Faivre, J;Marteau, P;Couillault, C;Senesse, P;Quipourt, V
通讯作者：
Quipourt, V
DOI：
10.1158/1055-9965.epi-08-0732
发表时间：
2009-01
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Daniel CR;Bostick RM;Flanders WD;Long Q;Fedirko V;Sidelnikov E;Seabrook ME
通讯作者：
Seabrook ME