A marker of endotoxemia is associated with obesity and related metabolic disorders in apparently healthy Chinese.
A marker of endotoxemia is associated with obesity and related metabolic disorders in apparently healthy Chinese.
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DOI：
10.2337/dc10-0340
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发表时间：
2010-09
期刊：
影响因子：
16.2
通讯作者：
Lin X
中科院分区：
文献类型：
--
作者：
Sun L;Yu Z;Ye X;Zou S;Li H;Yu D;Wu H;Chen Y;Dore J;Clément K;Hu FB;Lin X
脂多糖结合蛋白（LBP）升高是亚临床内毒素血症的一个标志物，可能参与肥胖和代谢风险的发病机制。我们旨在研究中国表面健康人群血浆LBP与代谢紊乱之间的关联。
在中国上海开展了一项基于人群的研究，纳入了559名超重/肥胖（体重指数[BMI]≥24.0 kg/m²）和500名体重正常（18.0≤BMI＜24.0 kg/m²）的35 - 54岁受试者。测量了空腹血糖、血脂谱、LBP、高敏C反应蛋白、白细胞介素 - 6、高分子量脂联素、瘦素、肝酶和身体成分。代谢综合征采用针对亚裔美国人更新的美国国家胆固醇教育计划成人治疗小组第三次报告标准进行定义。
超重/肥胖个体的LBP水平显著高于体重正常个体（几何均数为27.6 [95%置信区间25.2 - 30.3]对10.0 [95%置信区间9.1 - 11.1]μg/ml；P＜0.001）。在包括BMI在内的多项调整后，比较LBP最高四分位数与最低四分位数，代谢综合征和2型糖尿病的比值比分别为3.54（95%置信区间2.05 - 6.09）和5.53（95%置信区间2.64 - 11.59）。进一步对炎症标志物进行调整几乎消除了LBP与代谢综合征的显著关联，但未消除与2型糖尿病的关联，并且对脂肪因子和肝酶进行控制并未显著改变结果。
在中国表面健康人群中，循环LBP升高与肥胖、代谢综合征和2型糖尿病相关。这些发现表明脂多糖通过启动先天免疫机制在代谢紊乱中起作用。需要前瞻性研究来证实这些结果。
Elevated lipopolysaccharide-binding protein (LBP), a marker of subclinical endotoxemia, may be involved in the pathogenesis of obesity and metabolic risk. We aimed to investigate the association between plasma LBP and metabolic disorders in apparently healthy Chinese. A population-based study including 559 overweight/obese (BMI ≥24.0 kg/m2) and 500 normal-weight (18.0 ≤ BMI <24.0 kg/m2) subjects aged 35–54 years was conducted in Shanghai, China. Fasting plasma glucose, lipid profile, LBP, high-sensitivity C-reactive protein, interleukin-6, high-molecular-weight (HMW) adiponectin, leptin, hepatic enzymes, and body composition were measured. Metabolic syndrome was defined by the updated National Cholesterol Education Program Adult Treatment Panel III criterion for Asian Americans. LBP levels were significantly higher in overweight/obese individuals than in normal-weight individuals (geometric mean 27.6 [95% CI 25.2–30.3] vs. 10.0 [9.1–11.1] μg/ml; P < 0.001). After multiple adjustments including BMI, the odds ratios were 3.54 (95% CI 2.05–6.09) and 5.53 (95% CI 2.64–11.59) for metabolic syndrome and type 2 diabetes, respectively, comparing the highest with the lowest LBP quartile. Further adjustments for inflammatory markers almost abolished the significant association of LBP with metabolic syndrome but not that with type 2 diabetes, and controlling for adipokines and hepatic enzymes did not substantially alter the results. Elevated circulating LBP was associated with obesity, metabolic syndrome, and type 2 diabetes in apparently healthy Chinese. These findings suggested a role of lipopolysaccharide via initiation of innate immune mechanism(s) in metabolic disorders. Prospective studies are needed to confirm these results.
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影响因子：
7.7
作者：
Cani, Patrice D.;Amar, Jacques;Burcelin, Remy
通讯作者：
Burcelin, Remy
影响因子：
16.2
作者：
Ghanim H;Abuaysheh S;Sia CL;Korzeniewski K;Chaudhuri A;Fernandez-Real JM;Dandona P
通讯作者：
Dandona P
影响因子：
3.9
作者：
Weiss, J
通讯作者：
Weiss, J
DOI：
10.1152/ajpendo.00302.2006
发表时间：
2007-03-01
影响因子：
5.1
作者：
Creely, S. J.;McTernan, P. G.;Kumar, S.
通讯作者：
Kumar, S.
影响因子：
16.2
作者：
Nannipieri, M;Gonzales, C;Ferrannini, E
通讯作者：
Ferrannini, E