Purinergic Signaling in Mast Cell Degranulation and Asthma.
Purinergic Signaling in Mast Cell Degranulation and Asthma.
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肥大细胞脱颗粒与哮喘的嘌呤能信号传导。
DOI：
10.3389/fphar.2017.00947
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发表时间：
2017
影响因子：
5.6
通讯作者：
Jacobson KA
中科院分区：
文献类型：
--
作者：
Gao ZG;Jacobson KA
肥大细胞是造成大多数过敏性疾病的原因。最初认为几乎所有过敏事件仅通过高亲和力免疫球蛋白 E 受体直接介导。然而，最近的证据表明，许多其他受体，如 G 蛋白偶联受体和配体门控离子通道，也直接参与肥大细胞脱粒、组胺、丝氨酸蛋白酶、白三烯、肝素和血清素等炎症介质的释放。这些介质导致过敏性疾病如过敏性哮喘的症状。近年来，人们认识到，通过激活 G 蛋白偶联腺苷受体和 P2Y 核苷酸受体以及 ATP 门控 P2X 受体诱导的嘌呤能信号传导在肥大细胞脱颗粒中发挥着重要作用。腺苷和 ATP 均可单独诱导脱颗粒和支气管收缩，并与过敏原协同作用。所有三类受体（腺苷、P2X 和 P2Y）均参与气管粘液分泌。本综述将总结目前关于嘌呤能信号在肥大细胞脱颗粒及其最相关疾病哮喘中的作用的知识。
Mast cells are responsible for the majority of allergic conditions. It was originally thought that almost all allergic events were mediated directly only via the high-affinity immunoglobulin E receptors. However, recent evidence showed that many other receptors, such as G protein-coupled receptors and ligand-gated ion channels, are also directly involved in mast cell degranulation, the release of inflammatory mediators such as histamine, serine proteases, leukotrienes, heparin, and serotonin. These mediators are responsible for the symptoms in allergic conditions such as allergic asthma. In recent years, it has been realized that purinergic signaling, induced via the activation of G protein-coupled adenosine receptors and P2Y nucleotide receptors, as well as by ATP-gated P2X receptors, plays a significant role in mast cell degranulation. Both adenosine and ATP can induce degranulation and bronchoconstriction on their own and synergistically with allergens. All three classes of receptors, adenosine, P2X and P2Y are involved in tracheal mucus secretion. This review will summarize the currently available knowledge on the role of purinergic signaling in mast cell degranulation and its most relevant disease, asthma.
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影响因子：
7.3
作者：
Button B;Okada SF;Frederick CB;Thelin WR;Boucher RC
通讯作者：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1038/nrrheum.2016.178
发表时间：
2017-01
期刊：
Nature reviews. Rheumatology
影响因子：
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作者：
通讯作者：
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影响因子：
3.5
作者：
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通讯作者：
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DOI：
10.1124/jpet.115.229872
发表时间：
2016-02-01
影响因子：
3.5
作者：
Carlin, Jesse Lea;Tosh, Dilip K.;Reitman, Marc L.
通讯作者：
Reitman, Marc L.