Glycocalyx Curving the Membrane: Forces Emerging from the Cell Exterior.
Glycocalyx Curving the Membrane: Forces Emerging from the Cell Exterior.
复制标题
DOI：
10.1146/annurev-cellbio-120219-054401
复制
发表时间：
2021-10-06
影响因子：
11.3
通讯作者：
Paszek MJ
中科院分区：
文献类型：
--
作者：
Kuo JC;Paszek MJ
形态转变通常归因于蛋白质和脂类的作用。在膜的形状调控中，很大程度上被忽视的是糖萼，这是一种存在于人体所有细胞上的细胞周膜。由被称为葡聚糖的复杂的糖聚合物以及糖基化的脂类和蛋白质组成，糖萼是向质膜施加力的理想位置。大的、无结构的多糖和糖蛋白在糖萼中可以产生强大的拥挤压力，足以引起膜弯曲。应激也可能源于糖链，这些糖链在不对称分布的脂类上传递曲率偏好，被结合因子和感染剂利用来诱导形态变化。通过这些力量，糖萼可以对功能性细胞表面结构的生物发生以及细胞外小泡的分泌产生深远的影响。在这篇综述中，我们讨论了这些机制在正常健康和疾病中的最新证据和例子。
Morphological transitions are typically attributed to the actions of proteins and lipids. Largely overlooked in membrane shape regulation is the glycocalyx, a pericellular membrane coat that resides on all cells in the human body. Comprised of complex sugar polymers known as glycans as well as glycosylated lipids and proteins, the glycocalyx is ideally positioned to impart forces on the plasma membrane. Large, unstructured polysaccharides and glycoproteins in the glycocalyx can generate crowding pressures strong enough to induce membrane curvature. Stress may also originate from glycan chains that convey curvature preference on asymmetrically distributed lipids, which are exploited by binding factors and infectious agents to induce morphological changes. Through such forces, the glycocalyx can have profound effects on the biogenesis of functional cell surface structures as well as the secretion of extracellular vesicles. In this review, we discuss recent evidence and examples of these mechanisms in normal health and disease.
登录
查看更多内容
DOI：
10.1126/science.1223012
发表时间：
2012-08-24
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Button B;Cai LH;Ehre C;Kesimer M;Hill DB;Sheehan JK;Boucher RC;Rubinstein M
通讯作者：
Rubinstein M
影响因子：
3.9
作者：
Berndt, C;Montañez, E;Reina, M
通讯作者：
Reina, M
DOI：
10.1073/pnas.1009382107
发表时间：
2010-08-03
影响因子：
11.1
作者：
Burra, Sirisha;Nicolella, Daniel P.;Jiang, Jean X.
通讯作者：
Jiang, Jean X.
影响因子：
4.4
作者：
Blalock, Timothy D.;Spurr-Michaud, Sandra J.;Gipson, Ilene K.
通讯作者：
Gipson, Ilene K.
影响因子：
64.8
作者：
通讯作者：
--